Stem-loop rno-mir-135b

Accession

MI0000645

Description

Rattus norvegicus rno-mir-135b precursor miRNA

Literature search

89 open access papers mention rno-mir-135b
(164 sentences)

Sequence

61167 reads, 58.0 reads per million, 159 experiments

cgcucugcuguggccUAUGGCUUUUCAUUCCUAUGUGAuugcuguuccgaacucAUGUAGGGCUAAAAGCCAUGGGcuacagugaggggcaagcucc
.((((((((((((((((((((((((...(((((((((((((......)))..))))))))))..)))))))))))))))))))..))))).......

Structure

------c     --                   CAU          --   cu 
       gcucu  gcuguggccUAUGGCUUUU   UCCUAUGUGA  uug  g
       |||||  |||||||||||||||||||   ||||||||||  |||   
       cgggg  ugacaucGGGUACCGAAAA   GGGAUGUAcu  agc  u
ccucgaa     ag                   -UC          ca   cu 

Annotation confidence High

Comments

Kim et al. cloned 40 new miRNAs from rat E18 primary cortical neurons [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr13: 48976986-48977082 [+]

Mature rno-miR-135b-5p

• Accession: MIMAT0000611
• Description: Rattus norvegicus rno-miR-135b-5p mature miRNA
• Sequence: 16 - UAUGGCUUUUCAUUCCUAUGUGA - 38
• Evidence: experimental ; cloned [1-2], SOLiD [3]

Mature rno-miR-135b-3p

• Accession: MIMAT0017043
• Description: Rattus norvegicus rno-miR-135b-3p mature miRNA
• Sequence: 55 - AUGUAGGGCUAAAAGCCAUGGG - 76
• Evidence: experimental ; SOLiD [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249