Stem-loop hsa-mir-1-1

Accession

MI0000651

Symbol

HGNC: MIR1-1

Description

Homo sapiens hsa-mir-1-1 precursor miRNA

Literature search

517 open access papers mention hsa-mir-1-1
(2693 sentences)

Sequence

6744881 reads, 5442 reads per million, 153 experiments

ugggaaACAUACUUCUUUAUAUGCCCAUauggaccugcuaagcuaUGGAAUGUAAAGAAGUAUGUAUcuca
(((((.((((((((((((((((..((((((((.....)))...))))).)))))))))))))))).)))))

Structure

     a                GC     ---   a 
uggga ACAUACUUCUUUAUAU  CCAUa   ugg c
||||| ||||||||||||||||  |||||   ||| c
acucU UGUAUGAAGAAAUGUA  GGUau   auc u
     A                -A     cga   g 

Annotation confidence High

Comments

Lagos-Quintana et al. [1] reported the cloning of miR-1b, miR-1c and miR-1d. The mature processed miR sequences are identical apart from the 3' residues (A in mir-1b, C in mir-1c and UU in mir-1d). The 3' residues of both miR-1b and miR-1c conflict with the predicted stem-loop precursor sequence shown here and these sequences are not found in current assemblies of human and mouse genomes. It is suggested that polyA polymerase may add 1-3 nts to the 3' end of the mature transcript (Tom Tuschl, pers. comm.). The common 21 nts of the 3 reported miR sequences have been rationalised here and named miR-1. There are 2 pairs of orthologous putative hairpin precursor structures named mir-1-1 (human MIR:MI0000651, mouse MIR:MI0000139), and mir-1-2 (human MIR:MI0000437, mouse MIR:MI0000652). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr20: 62554306-62554376 [+]

Disease association

hsa-mir-1-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1-3p

• Accession: MIMAT0000416
• Description: Homo sapiens hsa-miR-1-3p mature miRNA
• Sequence: 46 - UGGAAUGUAAAGAAGUAUGUAU - 67
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-1-5p

• Accession: MIMAT0031892
• Description: Homo sapiens hsa-miR-1-5p mature miRNA
• Sequence: 7 - ACAUACUUCUUUAUAUGCCCAU - 28
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20158877
   Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
   Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
   BMC Genomics (2010) 11:S6


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739