miRBase entry: hsa-mir-1-1

Stem-loop hsa-mir-1-1

Homo sapiens hsa-mir-1-1 precursor miRNA
Gene family
MIPF0000038; mir-1

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1-1 is a type of miR1 in mammals that is mainly related to skeletal muscle development [PMC5424345]. In prostate cancer (PCa), miR-1 pretreatment was used to collect differentially expressed genes (DEGs), and the Gene Expression Omnibus (GEO) and ArrayExpress databases were searched with specific retrieval strategies [PMC6236292]. MIR1-1, along with other cardiac myomiRs, was found to be unperturbed in NKX2-5 knockout cardiomyocytes [PMC6828809]. The expression of MIR1-1, along with other myogenic miRNAs, was established during pluripotent stem cell differentiation into the cardiac lineage [PMC6828809]. MIR1-1 is a muscle-specific microRNA that is produced during the early stage of cardiogenesis [PMC7123062]. It has been implicated in the regulation of cardiac contraction and embryonic angiogenesis [PMC8624534]. SRF activates MIR1-1, along with miR133a, which regulates many mRNAs of MRTF-SRF target genes [PMC9185982]. MIR1-1 has been used as a target for mRNA co-delivery experiments in cardiomyocytes [PMC7832270]. It is embedded in the MIR1-1HG gene and promotes muscle differentiation and expression during myogenesis [PMC5137429]. In colorectal cancer (CRC), MIR1-1 and MIR133A2 had a copy number gain in approximately 7% of patients [PMC4967895]. The relative abundance of URA5 mRNA in samples with knockdown by miR1-1 was significantly lower compared to wild type samples [PMC3530498].

Literature search
517 open access papers mention hsa-mir-1-1
(2693 sentences)


6744881 reads, 5442 reads per million, 153 experiments

     a                GC     ---   a 
||||| ||||||||||||||||  |||||   ||| c
     A                -A     cga   g 

Annotation confidence High
Do you think this miRNA is real?
Lagos-Quintana et al. [1] reported the cloning of miR-1b, miR-1c and miR-1d. The mature processed miR sequences are identical apart from the 3' residues (A in mir-1b, C in mir-1c and UU in mir-1d). The 3' residues of both miR-1b and miR-1c conflict with the predicted stem-loop precursor sequence shown here and these sequences are not found in current assemblies of human and mouse genomes. It is suggested that polyA polymerase may add 1-3 nts to the 3' end of the mature transcript (Tom Tuschl, pers. comm.). The common 21 nts of the 3 reported miR sequences have been rationalised here and named miR-1. There are 2 pairs of orthologous putative hairpin precursor structures named mir-1-1 (human MIR:MI0000651, mouse MIR:MI0000139), and mir-1-2 (human MIR:MI0000437, mouse MIR:MI0000652). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr20: 62554306-62554376 [+]

Disease association
hsa-mir-1-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-1-3p

Accession MIMAT0000416
Description Homo sapiens hsa-miR-1-3p mature miRNA
Evidence experimental
cloned [2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-1-5p

Accession MIMAT0031892
Description Homo sapiens hsa-miR-1-5p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739