Stem-loop hsa-mir-155

Accession

MI0000681

Symbol

HGNC: MIR155

Description

Homo sapiens hsa-mir-155 precursor miRNA mir-155

Gene
family

RF00731; mir-155

Literature search

1009 open access papers mention hsa-mir-155
(8276 sentences)

Sequence

84128 reads, 459 reads per million, 127 experiments

cugUUAAUGCUAAUCGUGAUAGGGGUUuuugccuccaacugaCUCCUACAUAUUAGCAUUAACAg
((((((((((((((.(((.((((((((.(((....)))..)))))))))))))))))))))))))

Structure

              C   A        -u   c 
cugUUAAUGCUAAU GUG UAGGGGUU  uug c
|||||||||||||| ||| ||||||||  |||  
gACAAUUACGAUUA UAC AUCCUCag  aac u
              -   -        uc   c 

Annotation confidence High

Comments

Human mir-155 is predicted based on homology to a cloned miR from mouse (MIR:MI0000177) [1], and later experimentally validated in human HL-60 leukemia cells [2]. Like the mouse miRNA, human mir-155 resides in the non-coding BIC transcript (EMBL:AF402776), located on chromosome 21 [3]. The mature form differs from that in mouse at a single position. Eis et al. confirm that miR-155 is processed from the BIC transcript in human, and demonstrate elevated expression of miR-155 in lymphoma samples [4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context

chr21: 25573980-25574044 [+]

Disease association

hsa-mir-155 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-155 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-155 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-155-5p

• Accession: MIMAT0000646
• Description: Homo sapiens hsa-miR-155-5p mature miRNA
• Sequence: 4 - UUAAUGCUAAUCGUGAUAGGGGUU - 27
• Evidence: experimental ; cloned [2,5-7]

Mature hsa-miR-155-3p

• Accession: MIMAT0004658
• Description: Homo sapiens hsa-miR-155-3p mature miRNA
• Sequence: 43 - CUCCUACAUAUUAGCAUUAACA - 64
• Evidence: experimental ; cloned [5]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 17989717
   Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
   "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
   "Leukemia (2008) 22:330-338


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


7. PubMed ID: 15738415
   Accumulation of miR-155 and BIC RNA in human B cell lymphomas
   "Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE"
   "Proc Natl Acad Sci U S A (2005) 102:3627-3632