miRBase entry: hsa-mir-155

Stem-loop hsa-mir-155

Homo sapiens hsa-mir-155 precursor miRNA
Gene family
MIPF0000157; mir-155

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR155 is a noncoding transcript of the B-cell integration cluster gene that has been implicated in various biological processes and diseases, including osteogenesis, adipose tissue inflammation, autophagy, and cancer [PMC9288680] [PMC9839347] [PMC5617927] [PMC4389881] [PMC8761951]. It has been shown to play a role in osteogenic differentiation and bone regeneration, with its inhibition leading to increased osteogenesis of mesenchymal stem cells (MSCs) [PMC9288680]. MIR155 has also been found to be involved in adipose tissue inflammation and metabolic profile in an obesity setting, with its loss resulting in reduced M1 macrophage accumulation and improved metabolic profile [PMC5617927]. Additionally, MIR155 has been shown to regulate autophagic activity and is implicated in hypoxia-induced autophagy [PMC4389881]. It has also been reported that MIR155 expression does not affect the expression of anti-CD19 CAR (chimeric antigen receptor) in CAR retroviral vectors [PMC8761951]. Furthermore, MIR155 expression is reduced by certain anti-parasitic drugs in Th17 cells [PMC8169650]. The cell type-specific role of MIR155 in vascular calcification remains to be investigated using specific knockout or overexpression mouse models [PMC7810936]. In cancer research, MIR155 has been described as a key player involved in the pathogenesis of various hematologic malignancies and as part of exosomal cargo. It is also associated with breast cancer progression and diagnosis when examined along with other miRNAs such as miR10b, miR34a, and miR141. However, its association with ET resistance remains unknown. Additionally, MIR155 is known for its pro-inflammatory effects under hyperlipidemic conditions but not under normal conditions [PMC7912829] [PMC6607238] [PMC3338496].

Literature search
1009 open access papers mention hsa-mir-155
(8276 sentences)


84128 reads, 459 reads per million, 127 experiments

              C   A        -u   c 
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              -   -        uc   c 

Annotation confidence High
Do you think this miRNA is real?
Human mir-155 is predicted based on homology to a cloned miR from mouse (MIR:MI0000177) [1], and later experimentally validated in human HL-60 leukemia cells [2]. Like the mouse miRNA, human mir-155 resides in the non-coding BIC transcript (EMBL:AF402776), located on chromosome 21 [3]. The mature form differs from that in mouse at a single position. Eis et al. confirm that miR-155 is processed from the BIC transcript in human, and demonstrate elevated expression of miR-155 in lymphoma samples [4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context
chr21: 25573980-25574044 [+]

Disease association
hsa-mir-155 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-155 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-155 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-155-5p

Accession MIMAT0000646
Description Homo sapiens hsa-miR-155-5p mature miRNA
Evidence experimental
cloned [2,5-7]
Database links
Predicted targets

Mature hsa-miR-155-3p

Accession MIMAT0004658
Description Homo sapiens hsa-miR-155-3p mature miRNA
Evidence experimental
cloned [5]
Database links
Predicted targets


  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 17989717
    Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    "Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A"
    "Leukemia (2008) 22:330-338

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  6. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  7. PubMed ID: 15738415
    Accumulation of miR-155 and BIC RNA in human B cell lymphomas
    "Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E, Dahlberg JE"
    "Proc Natl Acad Sci U S A (2005) 102:3627-3632