Accession
MI0000703
Symbol
MGI:
Mir223
Description
Mus musculus
mmu-mir-223 precursor miRNA mir-223
Gene
family?
family?
RF00664;
mir-223
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Mmu-mir-223 is a microRNA that is upregulated in various biological contexts [PMC5617494]. In CD34+SCA1+ BMHSCs, the expression of mmu-mir-223 was found to be upregulated after treatment with CTX [PMC5617494]. Knocking out mmu-mir-223 resulted in the de-repression of exclusive targets with 8mer sites, indicating that the 5'-isomiR of mmu-mir-223 affected these targets [PMC3919606]. The expression levels of mmu-mir-223 were normalized against β-actin [PMC4755013]. In UVB irradiated mice, mmu-mir-223 was found to be upregulated compared to untreated mice [PMC3597329]. Mice with DSS-induced colitis were treated with mmu-mir-223 loaded nanoparticles, which resulted in therapeutic effects [PMC9024817]. Mmu-mir-223 mimic treatment repressed the expression of NLRP3 and increased the repression of IL-1β, IL-6, TNF-α, and CXCL1 and CXCL2 mRNA transcripts [PMC6113393]. G1 arrest and the presence of p27 regulated three miRs including mir233 [PMC4012735]. Several miRNAs including mir233 increased their expression significantly at different times post-infection [PMC9861972].
Literature search
185 open access papers mention mmu-mir-223
(2051 sentences)
(2051 sentences)
Sequence
516726
reads,
2285
reads per million, 96 experiments
ucuggccaucugcagugucacgcucCGUGUAUUUGACAAGCUGAGUUGgacacucugugugguagagUGUCAGUUUGUCAAAUACCCCAaguguggcucaugccuaucag
.((((......((((.((((((((..(.((((((((((((((......(((((((((.....))))))))))))))))))))))).)..)))))))).).)))...))))
.((((......((((.((((((((..(.((((((((((((((......(((((((((.....))))))))))))))))))))))).)..)))))))).).)))...))))
Structure
u ccaucu - u cC U GAGUUG u cugg gca g gucacgcu G GUAUUUGACAAGCU gacacucug g |||| ||| | |||||||| | |||||||||||||| ||||||||| u gacu cgu c cgguguga C CAUAAACUGUUUGA CUGUgagau g - ---auc a u AC C ------ g
Annotation confidence
High
Do you think this miRNA is real?
Comments
Mouse mir-223 is predicted [2] based on homology to a reported miR from human (MIR:MI0000300) [1]. Its expression was later verified by cloning [3].
Genome context
chrX: 96242817-96242926 [+]
Database links
Mature mmu-miR-223-5p
| Accession | MIMAT0017056 |
| Description | Mus musculus mmu-miR-223-5p mature miRNA |
| Sequence | 26 - CGUGUAUUUGACAAGCUGAGUUG - 48 |
| Evidence |
experimental
Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature mmu-miR-223-3p
| Accession | MIMAT0000665 |
| Description | Mus musculus mmu-miR-223-3p mature miRNA |
| Sequence | 68 - UGUCAGUUUGUCAAAUACCCCA - 89 |
| Evidence |
experimental
cloned [3], Illumina [4-5] |
| Database links |
|
| Predicted targets |
|
References
|
