Stem-loop mmu-mir-320

Accession

MI0000704

Symbol

MGI: Mir320

Description

Mus musculus mmu-mir-320 precursor miRNA mir-320

Gene
family

RF00736; mir-320

Literature search

59 open access papers mention mmu-mir-320
(226 sentences)

Sequence

1234184 reads, 3881 reads per million, 107 experiments

gccucgccgcccuccGCCUUCUCUUCCCGGUUCUUCCcggagucgggAAAAGCUGGGUUGAGAGGGCGAaaaaggauguggg
..(((((..((...(((((((((..(((((((.((((((....)))))).)))))))..))))))))).....))..)))))

Structure

gc     cg  --cuc         UU       C      g 
  cucgc  cc     cGCCUUCUC  CCCGGUU UUCCcg a
  |||||  ||     |||||||||  ||||||| ||||||  
  gggug  gg     GCGGGAGAG  GGGUCGA AAgggc g
--     ua  aaaaA         UU       A      u 

Annotation confidence High

Comments

Mouse mir-320 is predicted [2] based on homology to a cloned miR from human (MIR:MI0000542) [1]. Its expression was later verified in mouse [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr14: 70443510-70443591 [+]

Mature mmu-miR-320-5p

• Accession: MIMAT0017057
• Description: Mus musculus mmu-miR-320-5p mature miRNA
• Sequence: 16 - GCCUUCUCUUCCCGGUUCUUCC - 37
• Evidence: experimental ; Illumina [6]

Mature mmu-miR-320-3p

• Accession: MIMAT0000666
• Description: Mus musculus mmu-miR-320-3p mature miRNA
• Sequence: 48 - AAAAGCUGGGUUGAGAGGGCGA - 69
• Evidence: experimental ; cloned [3-4], Illumina [5-6]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73