Stem-loop mmu-mir-224

Accession

MI0000711

Symbol

MGI: Mir224

Description

Mus musculus mmu-mir-224 precursor miRNA mir-224

Gene
family

RF00680; mir-224

Literature search

44 open access papers mention mmu-mir-224
(150 sentences)

Sequence

12653 reads, 30 reads per million, 79 experiments

gggcuuuUAAGUCACUAGUGGUUCCGUUuaguagaugguuugugcauuguuucaAAAUGGUGCCCUAGUGACUACAaagccc
(((((((..(((((((((.(((.((((((.(..((((.......))))....).)))))).))))))))))))..)))))))

Structure

       UA         U   U      a --ua    gu 
gggcuuu  AGUCACUAG GGU CCGUUu g    gaug  u
|||||||  ||||||||| ||| |||||| |    ||||  u
cccgaaA  UCAGUGAUC CCG GGUAAA c    uuac  g
       CA         -   U      a uuug    gu 

Annotation confidence Low

Comments

Mouse mir-224 is predicted [2] based on homology to a cloned miR from human (MIR:MI0000301) [1]. Its expression was later verified by cloning [3].

Genome context

chrX: 72261031-72261112 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-224

Mature mmu-miR-224-5p

• Accession: MIMAT0000671
• Description: Mus musculus mmu-miR-224-5p mature miRNA
• Sequence: 8 - UAAGUCACUAGUGGUUCCGUU - 28
• Evidence: experimental ; cloned [3], Illumina [4-5]

Mature mmu-miR-224-3p

• Accession: MIMAT0017062
• Description: Mus musculus mmu-miR-224-3p mature miRNA
• Sequence: 55 - AAAUGGUGCCCUAGUGACUACA - 76
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73