Accession
MI0000727
Symbol
HGNC:
MIR128-2
Description
Homo sapiens
hsa-mir-128-2 precursor miRNA mir-128
Gene
family?
family?
RF00649;
mir-128
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR128-2 is a miRNA that has been found to be recurrently aberrant in expression in various studies [PMC3566410]. Mutant TP53 has been shown to bind to the putative promoter of the MIR128-2 host gene ARPP21, leading to increased expression of both miR-128 and ARPP21 mRNA [PMC4302087]. A mutation in the MIR128-2 gene, specifically the A13G mutation, has been found to reduce the processing of pri-miR-128-2 and result in glucocorticoid resistance in t(4;11) ALL cells [PMC9406077]. Additionally, mutp53 R175H has been shown to induce the expression of MIR128-2, which targets E2F5 and confers resistance to various cancer treatments [PMC7749743]. MIR128-1 and MIR128-2 are members of the miRNA MIR128 family and encode the same mature miR-128, which plays different roles in tumorigenesis depending on cancer type [PMC7802300]. A three-miRNA signature called miGISig, which includes MIR421, MIR128-1, and MIR128-2, has been identified as predictive of gastrointestinal (GI) cancer and clinical outcome [PMC7802300]. Dysregulation of both MIR128-1 and MIR128-2 has also been observed in glioblastomas [PMC3821381]. The genes encoding miR-128 transcripts are located on different chromosomes (MIR128 family on chromosome 3p22; ARPP21 gene on chromosome 3p22) but encode identical mature sequences with slight differences in their 5p species [PMC5481840].
Literature search
174 open access papers mention hsa-mir-128-2
(979 sentences)
(979 sentences)
Sequence
175904
reads,
1106
reads per million, 134 experiments
ugugcagugggaagGGGGGCCGAUACACUGUACGAGAgugaguagcaggucUCACAGUGAACCGGUCUCUUUcccuacuguguc
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...
Structure
ugu a AUA AC g gag gcaguggg agGGGGGCCG CACUGU GAGA u u |||||||| |||||||||| |||||| |||| | ugucaucc UUUCUCUGGC GUGACA CUcu g a cug c CAA -- g acg
Annotation confidence
High
Do you think this miRNA is real?
Comments
The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.
Genome context
chr3: 35744476-35744559 [+]
Disease association
hsa-mir-128-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-128-3p
| Accession | MIMAT0000424 |
| Description | Homo sapiens hsa-miR-128-3p mature miRNA |
| Sequence | 52 - UCACAGUGAACCGGUCUCUUU - 72 |
| Evidence |
experimental
cloned [3], Illumina [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-128-2-5p
| Accession | MIMAT0031095 |
| Description | Homo sapiens hsa-miR-128-2-5p mature miRNA |
| Sequence | 15 - GGGGGCCGAUACACUGUACGAGA - 37 |
| Evidence |
experimental
Illumina [4] |
References
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