miRBase entry: hsa-mir-194-2

Stem-loop hsa-mir-194-2

HGNC: MIR194-2
Homo sapiens hsa-mir-194-2 precursor miRNA
Gene family
MIPF0000055; mir-194

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR194-2 is a miRNA cluster located on chromosome 11q13.1 [PMC6120784]. It is part of the MIR192-194-2 cluster, which has been reported to respond to p53 activation [PMC6120784]. MIR194-1 and MIR194-2, although located on different chromosomes, share an identical mature sequence and target the same type of mRNAs [PMC6120784]. The methylation levels at MIR194-2 were observed using the Mann-Whitney test to compare squamous and Barrett's groups [PMC6120784]. The coexpression of MIR192 and MIR194-2 in Barrett's esophagus (BE) was investigated in relation to genomic and epigenetic alterations [PMC6120784]. In a study on miRNA expression signatures, MIR194-2 was among the top-ranked miRNAs [PMC9284388]. It has also been found to be upregulated in lung cancer and downregulated in epilepsy patients, suggesting its potential as a diagnostic biomarker for these conditions [PMC3143163] [PMC7465068]. Additionally, an SNP in MIR194-2 was shown to be differentially expressed in lung cancer [PMC3143163]. The upregulation of miR194-1 and MIR194-2 demonstrated good diagnostic performance for certain conditions, with AUROC values of 0.946 and 0.940, respectively [PMC6005310]. In patients with focal cortical dysplasia (FCD), exosomal miRNAs including MIR194-2 were found to be upregulated in circulating serum exosomes [PMC7465068]. Overall, these findings highlight the potential role of MIR194-2 as a biomarker for various diseases.

Literature search
142 open access papers mention hsa-mir-194-2
(1015 sentences)


60146 reads, 297 reads per million, 148 experiments

-      c      cU         A      G    agu   c 
 ugguuc cgcccc  GUAACAGCA CUCCAU UGGA   gcc a
 |||||| ||||||  ||||||||| |||||| ||||   |||  
 accggg gcgggG  UAUUGUCGU GGGGUG ACCu   ugg c
g      a      UC         C      -    ---   u 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MIR:MI0000236) on chromosome 1, and mir-194-2 (MIR:MI0000733) on chromosome 19) and human (mir-194-1 (MIR:MI0000488) on chromosome 1, and mir-194-2 (MIR:MI0000732) on chromosome 11).

Genome context
chr11: 64891355-64891439 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-194-2
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-194-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-194-5p

Accession MIMAT0000460
Description Homo sapiens hsa-miR-194-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-194-3p

Accession MIMAT0004671
Description Homo sapiens hsa-miR-194-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179