Accession
MI0000732
Symbol
HGNC:
MIR194-2
Description
Homo sapiens
hsa-mir-194-2 precursor miRNA mir-194
Gene
family?
family?
RF00257;
mir-194
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR194-2 is a microRNA (miRNA) that is part of the MIR192-194-2 cluster located on chromosome 11q13.1 and is known to be upregulated in response to p53 activation [PMC6120784]. This miRNA shares an identical mature sequence with MIR194-1, despite being located on different chromosomes, and they both target the same mRNAs [PMC6120784]. In a study comparing squamous and Barrett’s groups, differences in methylation levels of MIR192 and MIR194-2 were observed using the Mann-Whitney test [PMC6120784]. The study also noted an increased coexpression of MIR192 and MIR194-2 in Barrett’s Esophagus (BE), prompting investigations into genomic and epigenetic alterations that could explain this phenomenon [PMC6120784]. Furthermore, MIR194-2 has been identified as part of a molecular feature group with a significant negative correlation with certain transcriptional modules [PMC8360386]. It has also demonstrated good diagnostic performance for certain conditions, with high area under the receiver operating characteristic (AUROC) values [PMC6005310]. Additionally, single nucleotide polymorphisms (SNPs) in MIR194-2 have been associated with differential expression in diseases such as lung cancer [PMC3143163], while its expression alongside other miRNAs has been implicated in the regulation of genes important for various cellular processes [PMC7465068]. Notably, alterations in the levels of this miRNA have been suggested as potential biomarkers for diseases like epilepsy due to its differential expression patterns observed in patients compared to controls [PMC7465068].
Literature search
142 open access papers mention hsa-mir-194-2
(1015 sentences)
(1015 sentences)
Sequence
60146
reads,
297
reads per million, 148 experiments
ugguucccgcccccUGUAACAGCAACUCCAUGUGGAagugcccacugguuCCAGUGGGGCUGCUGUUAUCUGgggcgagggccag
((((((.((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..)))))).)))))).
((((((.((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..)))))).)))))).
Structure
- c cU A G agu c ugguuc cgcccc GUAACAGCA CUCCAU UGGA gcc a |||||| |||||| ||||||||| |||||| |||| ||| accggg gcgggG UAUUGUCGU GGGGUG ACCu ugg c g a UC C - --- u
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MIR:MI0000236) on chromosome 1, and mir-194-2 (MIR:MI0000733) on chromosome 19) and human (mir-194-1 (MIR:MI0000488) on chromosome 1, and mir-194-2 (MIR:MI0000732) on chromosome 11).
Genome context
chr11: 64891355-64891439 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-194-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-194-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-194-5p
| Accession | MIMAT0000460 |
| Description | Homo sapiens hsa-miR-194-5p mature miRNA |
| Sequence | 15 - UGUAACAGCAACUCCAUGUGGA - 36 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-194-3p
| Accession | MIMAT0004671 |
| Description | Homo sapiens hsa-miR-194-3p mature miRNA |
| Sequence | 51 - CCAGUGGGGCUGCUGUUAUCUG - 72 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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