Stem-loop hsa-mir-194-2

Accession

MI0000732

Symbol

HGNC: MIR194-2

Description

Homo sapiens hsa-mir-194-2 precursor miRNA mir-194

Gene
family

RF00257; mir-194

Literature search

142 open access papers mention hsa-mir-194-2
(1015 sentences)

Sequence

60143 reads, 96 reads per million, 148 experiments

ugguucccgcccccUGUAACAGCAACUCCAUGUGGAagugcccacugguuCCAGUGGGGCUGCUGUUAUCUGgggcgagggccag
((((((.((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..)))))).)))))).

Structure

-      c      cU         A      G    agu   c 
 ugguuc cgcccc  GUAACAGCA CUCCAU UGGA   gcc a
 |||||| ||||||  ||||||||| |||||| ||||   |||  
 accggg gcgggG  UAUUGUCGU GGGGUG ACCu   ugg c
g      a      UC         C      -    ---   u 

Annotation confidence High

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MIR:MI0000236) on chromosome 1, and mir-194-2 (MIR:MI0000733) on chromosome 19) and human (mir-194-1 (MIR:MI0000488) on chromosome 1, and mir-194-2 (MIR:MI0000732) on chromosome 11).

Genome context

chr11: 64891355-64891439 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-194-2

Disease association

hsa-mir-194-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-194-5p

• Accession: MIMAT0000460
• Description: Homo sapiens hsa-miR-194-5p mature miRNA
• Sequence: 15 - UGUAACAGCAACUCCAUGUGGA - 36
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-194-3p

• Accession: MIMAT0004671
• Description: Homo sapiens hsa-miR-194-3p mature miRNA
• Sequence: 51 - CCAGUGGGGCUGCUGUUAUCUG - 72
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179