Stem-loop mmu-mir-194-2

Accession

MI0000733

Symbol

MGI: Mir194-2

Description

Mus musculus mmu-mir-194-2 precursor miRNA mir-194

Gene
family

RF00257; mir-194

Literature search

56 open access papers mention mmu-mir-194-2
(243 sentences)

Sequence

180618 reads, 970 reads per million, 103 experiments

guggcucccacccucUGUAACAGCAACUCCAUGUGGAagugcccacugguuCCAGUGGGGCUGCUGUUAUCUGggguggcggcuag
.(((((.(((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..))))))).))))).

Structure

g     c       cU         A      G    agu   c 
 uggcu ccacccu  GUAACAGCA CUCCAU UGGA   gcc a
 ||||| |||||||  ||||||||| |||||| ||||   |||  
 aucgg ggugggG  UAUUGUCGU GGGGUG ACCu   ugg c
g     c       UC         C      -    ---   u 

Annotation confidence High

Comments

Lagos-Quintana cloned miR-194 from mouse kidney tissue [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MIR:MI0000236) on chromosome 1, and mir-194-2 (MIR:MI0000733) on chromosome 19) and human (mir-194-1 (MIR:MI0000488) on chromosome 1, and mir-194-2 (MIR:MI0000732) on chromosome 11).

Genome context

chr19: 6264643-6264728 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-194-2

Mature mmu-miR-194-5p

• Accession: MIMAT0000224
• Description: Mus musculus mmu-miR-194-5p mature miRNA
• Sequence: 16 - UGUAACAGCAACUCCAUGUGGA - 37
• Evidence: experimental ; cloned [1,3], Illumina [4-5]

Mature mmu-miR-194-2-3p

• Accession: MIMAT0017073
• Description: Mus musculus mmu-miR-194-2-3p mature miRNA
• Sequence: 52 - CCAGUGGGGCUGCUGUUAUCUG - 73
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009