Stem-loop hsa-mir-29c

Accession

MI0000735

Symbol

HGNC: MIR29C

Description

Homo sapiens hsa-mir-29c precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR29C is a microRNA that is involved in various biological processes [PMC6219092]. It has been found that suppression of MIR29C in goose fatty liver promotes cell growth and enhances tolerance to severe steatosis [PMC6219092]. The expression of MIR29C is elevated in lncRNA HOXA-AS3 knockdown cell lines [PMC8489150]. Furthermore, the transcription factor MYC represses the expression of MIR29C, leading to increased expression of MCT1 on tumor cells [PMC5406861]. Two mRNA, VEGFA and SERPINE1, are regulated by multiple microRNAs including MIR29C [PMC5770416]. These microRNAs, including MIR29C, can be combined as a panel to predict hepatocellular carcinoma using a calculation formula [PMC9537616].

Literature search

512 open access papers mention hsa-mir-29c
(2674 sentences)

Sequence

388191 reads, 2141 reads per million, 135 experiments

aucucuuacacaggcUGACCGAUUUCUCCUGGUGUUCagagucuguuuuugucUAGCACCAUUUGAAAUCGGUUAugauguaggggga
..((((((((((...(((((((((((...(((((((.(((...........))))))))))...))))))))))))).))))))))..

Structure

au        -  ggc           UCC       C   gucu 
  cucuuaca ca   UGACCGAUUUC   UGGUGUU aga    g
  |||||||| ||   |||||||||||   ||||||| |||    u
  ggggaugu gu   AUUGGCUAAAG   ACCACGA Ucu    u
ag        a  ---           UUU       -   guuu 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr1: 207801852-207801939 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-29c

Disease association

hsa-mir-29c is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-29c-5p

• Accession: MIMAT0004673
• Description: Homo sapiens hsa-miR-29c-5p mature miRNA
• Sequence: 16 - UGACCGAUUUCUCCUGGUGUUC - 37
• Evidence: experimental ; cloned [3]

Mature hsa-miR-29c-3p

• Accession: MIMAT0000681
• Description: Homo sapiens hsa-miR-29c-3p mature miRNA
• Sequence: 54 - UAGCACCAUUUGAAAUCGGUUA - 75
• Evidence: experimental ; cloned [2-4]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739