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MIR34B is a member of the miR34 family and has been observed to be present only in the MB436 cell line, which is a subtype of triple-negative breast cancer (TNBC) [PMC8261273]. The miR34 family, which includes miR34A, MIR34B, and miR34C, has been recognized as tumor suppressors and has been implicated in various cellular processes that control carcinogenesis [PMC4039115]. These processes include cell cycling, apoptosis, somatic cell reprogramming, and metastasis [PMC4039115]. The presence of MIR34B in the MB436 cell line suggests its potential role as a tumor suppressor in TNBC. The miR34 family's involvement in cellular processes that regulate carcinogenesis highlights its significance in cancer development and progression. Understanding the specific functions of MIR34B within these processes could provide valuable insights into TNBC pathogenesis and potential therapeutic targets. Further research is needed to elucidate the precise mechanisms by which MIR34B functions as a tumor suppressor and its potential implications for TNBC treatment [PMC4039115].
cg -gUA UCA C - g
gugcu guuu GGCAGUG UUAG UGAUUGua cu u
||||| |||| ||||||| |||| |||||||| || g
cacgg caaa CCGUCAC AAUC ACUAACau gg g
aa acUA CUC - u u
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Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells , and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) and miR-34a (MIR:MI0000584) to clarify homology with human sequences. The predominant mature miRNA in human is expressed from the 3' arm (in contrast to previous annotation) . Both arms express mature products in mouse.