Accession
MI0000743
Symbol
HGNC:
MIR34C
Description
Homo sapiens
hsa-mir-34c precursor miRNA mir-34
Gene
family?
family?
RF00456;
mir-34
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR34C is a microRNA implicated in the regulation of gene expression, including the gene Bcl-2, which is known to play a role in cell survival and apoptosis [PMC4067617]. In a study where embryos were treated with VFm34cI, an inhibitor of MIR34C, an increase in Bcl-2 expression was observed on the first day post-treatment [PMC4067617]. This suggests that the VisuFect-mediated delivery of MIR34C inhibitor was successful and that the inhibitor was functioning effectively within the zygotes [PMC4067617]. Additionally, to assess the impact of Zika virus infection on MIR34C expression levels, real-time PCR assays were conducted on three different clones [PMC6425033]. This analysis confirmed that Zika infection induces changes in MIR34C expression [PMC6425033], which could have implications for understanding how Zika virus affects embryonic development and gene regulation.
Literature search
448 open access papers mention hsa-mir-34c
(2624 sentences)
(2624 sentences)
Sequence
171442
reads,
456
reads per million, 102 experiments
agucuaguuacuAGGCAGUGUAGUUAGCUGAUUGCuaauaguaccAAUCACUAACCACACGGCCAGGuaaaaagauu
.((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))).
.((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))).
Structure
a ag A A A C C a gucu uuacu GGC GUGU GUUAG UGAUUG ua u |||| ||||| ||| |||| ||||| |||||| || uaga aauGG CCG CACA CAAUC ACUAAc au a u aa A G C - c g
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells [1], and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) and miR-34a (MIR:MI0000584) to clarify homology with human sequences.
Genome context
chr11: 111513439-111513515 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-34c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-34c is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-34c is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-34c is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-34c-5p
| Accession | MIMAT0000686 |
| Description | Homo sapiens hsa-miR-34c-5p mature miRNA |
| Sequence | 13 - AGGCAGUGUAGUUAGCUGAUUGC - 35 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-34c-3p
| Accession | MIMAT0004677 |
| Description | Homo sapiens hsa-miR-34c-3p mature miRNA |
| Sequence | 46 - AAUCACUAACCACACGGCCAGG - 67 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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