miRBase entry: hsa-mir-299

Stem-loop hsa-mir-299


Accession
MI0000744
Symbol
HGNC: MIR299
Description
Homo sapiens hsa-mir-299 precursor miRNA mir-299
Gene
family?
RF00756; mir-299

Literature search
55 open access papers mention hsa-mir-299
(217 sentences)

Sequence

4942 reads, 137 reads per million, 109 experiments
aagaaaUGGUUUACCGUCCCACAUACAUuuugaauaugUAUGUGGGAUGGUAAACCGCUUcuu
(((((.((((((((((((((((((((((.......)))))))))))))))))))))).)))))

Structure
     a                      uu 
aagaa UGGUUUACCGUCCCACAUACAU  u
||||| ||||||||||||||||||||||  g
uucUU GCCAAAUGGUAGGGUGUAUgua  a
     C                      ua 


Annotation confidence High
Do you think this miRNA is real?
Comments
The sequence from the 5' arm of this miRNA precursor is the predicted human homologue of mouse miR-299, cloned from mouse embryonic stem cells [1,2], later validated in human [4]. Altuvia et al [3] report the cloning of a miRNA sequence from the 3' arm of the same precursor in human.

Genome context
chr14: 101023794-101023856 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-299
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-299 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-299-5p

Accession MIMAT0002890
Description Homo sapiens hsa-miR-299-5p mature miRNA
Sequence 7 - UGGUUUACCGUCCCACAUACAU - 28
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-299-3p

Accession MIMAT0000687
Description Homo sapiens hsa-miR-299-3p mature miRNA
Sequence 39 - UAUGUGGGAUGGUAAACCGCUU - 60
Evidence experimental
cloned [3-4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12919684
    Embryonic stem cell-specific MicroRNAs
    "Houbaviy HB, Murray MF, Sharp PA"
    "Dev Cell (2003) 5:351-358

  3. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  4. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706