Accession
MI0000746
Symbol
HGNC:
MIR99B
Description
Homo sapiens
hsa-mir-99b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR99B is a microRNA that is part of the human transcriptional unit AY358799, located downstream of a cluster of three microRNAs (MIR99B, LET7E, miR125A) [PMC3783845]. Blocking the expression of MIR99B has been shown to restrict bacterial growth [PMC3576108]. MIR99B is highly expressed and an outlier in the distribution array [PMC7912193]. It targets several genes and is the second most expressed miRNA [PMC7912193]. MIR99B has been found in EVs and is associated with pancreatic cancer cells and AML cell-derived EXs [PMC9171400] [PMC7100658]. It has also been implicated in breast cancer metastases, endometrial cancer, and NASH [PMC5705145] [PMC6994408] [PMC9818030]. MIR99B has been shown to target IGF1R and participate in the shutdown of signal transduction pathways involving NF-κB pathways [PMC4290566]. It is part of a cluster with MIR125A and MIR7E on chromosome 19 [PMC3573016] and has been found to be upregulated in CF airway epithelial cell lines compared to non-CF controls [PMC7493015]. The functionality of MIR99B has been associated with carcinogenesis, as dysregulation of both mature miRNAs produced by MIR99B (hsa-miR-99b-3p and hsa-miR-99b-5p) have been linked to cancer development. Mutations within miRNAs can also be associated with cancer development. The role of MIR99B in macrophage activation regulation remains complex.
Literature search
137 open access papers mention hsa-mir-99b
(407 sentences)
(407 sentences)
Sequence
662095
reads,
1445
reads per million, 130 experiments
ggcaccCACCCGUAGAACCGACCUUGCGgggccuucgccgcacaCAAGCUCGUGUCUGUGGGUCCGuguc
(((((..(((((((((..(((.((((.(.(((....))).)...)))).)))..)))))))))..)))))
(((((..(((((((((..(((.((((.(.(((....))).)...)))).)))..)))))))))..)))))
Structure
cC AC C --C g c
ggcac ACCCGUAGA CGA CUUG G ggc u
||||| ||||||||| ||| |||| | |||
cuguG UGGGUGUCU GCU GAAC c ccg u
CC GU C aca g c
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue of mouse miR-99b, cloned from mouse brain [1] and embryonic stem cells [2,3]. Its expression was later validated in human [4-6].
Genome context
chr19: 51692612-51692681 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-99b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-99b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-99b-5p
| Accession | MIMAT0000689 |
| Description | Homo sapiens hsa-miR-99b-5p mature miRNA |
| Sequence | 7 - CACCCGUAGAACCGACCUUGCG - 28 |
| Evidence |
experimental
cloned [4-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-99b-3p
| Accession | MIMAT0004678 |
| Description | Homo sapiens hsa-miR-99b-3p mature miRNA |
| Sequence | 45 - CAAGCUCGUGUCUGUGGGUCCG - 66 |
| Evidence |
experimental
cloned [5] |
| Database links |
|
| Predicted targets |
|
References
|
