miRBase entry: hsa-mir-296

Stem-loop hsa-mir-296

Homo sapiens hsa-mir-296 precursor miRNA
Gene family
MIPF0000159; mir-296

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR296 is an imprinted gene that has been studied in various contexts. It has been found to be hypomethylated in most cases of oral squamous cell carcinoma (OSCC) [PMC5558660]. Additionally, MIR296 has been identified as one of the miRNAs that have complementary sequences to HCV RNA [PMC9780829]. It has also been detected in GM12878 and MCF7 cells, as predicted by read-through transcription units [PMC6824518]. Dysregulation of MIR296 has been observed in the placenta of preeclampsia patients [PMC4464490]. Furthermore, MIR296 is one of the miRNAs found in extracellular vesicles (EVs) derived from periodontal ligament stem cells (PDLSCs) [PMC8745761]. In developmental studies, MIR296 and Mir298 were expressed in mesoderm and endoderm but not ectoderm [PMC8713755]. In stem cells, miR470, along with miR134 and MIR296, plays a role in modulating self-renewal and differentiation by targeting core stemness factors such as Oct4 and Nanog [PMC3772775]. The expression of MIR296 has also been investigated in acute promyelocytic leukemia (APL), with the aim of predicting prognosis [PMC8993542]. Finally, it was found that MIR296 is upregulated 33-fold in cells with a specific genetic variant (MIR204SNP) [PMC4695081].

Literature search
83 open access papers mention hsa-mir-296
(498 sentences)


5973 reads, 139 reads per million, 90 experiments

a   -      ca       C  C         G   ugc 
 gga cccuuc  gAGGGCC CC CUCAAUCCU Uug   c
 ||| ||||||  ||||||| || ||||||||| |||   u
 ucu gggaag  CUCUCGG GG GGGUUGGGA Gac   a
-   c      uC       A  U         -   uua 

Annotation confidence High
Do you think this miRNA is real?
This sequence is the predicted human homologue of mouse miR-296 cloned from mouse embryonic stem cells [1,3]. Its expression has also been verified in human ES cells [2].

Genome context
chr20: 58817615-58817694 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-296
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-296 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-296-5p

Accession MIMAT0000690
Description Homo sapiens hsa-miR-296-5p mature miRNA
Evidence experimental
cloned [2,4-5]
Database links
Predicted targets

Mature hsa-miR-296-3p

Accession MIMAT0004679
Description Homo sapiens hsa-miR-296-3p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 12919684
    Embryonic stem cell-specific MicroRNAs
    "Houbaviy HB, Murray MF, Sharp PA"
    "Dev Cell (2003) 5:351-358

  5. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73