Accession
MI0000762
Symbol
HGNC:
MIR362
Description
Homo sapiens
hsa-mir-362 precursor miRNA mir-362
Gene
family?
family?
RF04267;
mir-362
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR362 is a microRNA (miRNA) that is part of a cluster located within the third intron of the CLCN5 gene on the X chromosome [PMC8253104]. It is regulated by TERT and is known to be involved in various cancer types, acting as an oncomiR [PMC8253104]. Specifically, MIR362 has been implicated in the upregulation of gastric cancer tissues, contributing to increased cell proliferation and resistance to apoptosis [PMC4241533]. It has been observed that certain lung cancer cell lines, such as H1299 and 95-D, express higher levels of MIR362 compared to others like H460 and A549 [PMC6093061]. Furthermore, MIR362 has been identified as a potential regulator of target mRNAs in correlation analysis studies [PMC9097102]'>PMC9097102], and its relationship with target mRNAs has been investigated using inhibitors in BCPAP cells [PMC9097102]. Additionally, MIR362 has been recognized for its role in adipose tissue development and metabolism, with depot-specific effects observed upon Dicer deficiency in mice studies [PMC4892883].
Literature search
41 open access papers mention hsa-mir-362
(140 sentences)
(140 sentences)
Sequence
19749
reads,
208
reads per million, 124 experiments
cuugAAUCCUUGGAACCUAGGUGUGAGUgcuauuucagugcAACACACCUAUUCAAGGAUUCAaa
.(((((((((((((...((((((((.(((((.....)))))..))))))))))))))))))))).
.(((((((((((((...((((((((.(((((.....)))))..))))))))))))))))))))).
Structure
c ACC -A a uugAAUCCUUGGA UAGGUGUG GUgcu u ||||||||||||| |||||||| ||||| u aACUUAGGAACUU AUCCACAC cguga u a --- AA c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 50008964-50009028 [+]
Clustered miRNAs
7 other miRNAs are < 10 kb from hsa-mir-362
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-362 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-362-5p
| Accession | MIMAT0000705 |
| Description | Homo sapiens hsa-miR-362-5p mature miRNA |
| Sequence | 5 - AAUCCUUGGAACCUAGGUGUGAGU - 28 |
| Evidence |
experimental
array-cloned [1], cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-362-3p
| Accession | MIMAT0004683 |
| Description | Homo sapiens hsa-miR-362-3p mature miRNA |
| Sequence | 42 - AACACACCUAUUCAAGGAUUCA - 63 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
|
