Stem-loop hsa-mir-363

Accession

MI0000764

Symbol

HGNC: MIR363

Description

Homo sapiens hsa-mir-363 precursor miRNA mir-363

Gene
family

RF01898; mir-363

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR363 is a microRNA that has been implicated in prostate cancer (PCa) [PMC10067432]. RNA immunoprecipitation (RIP) assays have shown that MIR363 is associated with the RNA-induced silencing complex component Argonaute 2 (Ago2), which suggests a role in gene silencing [PMC10067432]. Additionally, MIR363 expression levels are significantly reduced in prostate cancer tissues and cell lines, including PC3 and DU145, compared to benign prostatic hyperplasia (BPH), suggesting that MIR363 may function as a tumor suppressor or serve as a biomarker in PCa [PMC10067432].

Literature search

76 open access papers mention hsa-mir-363
(499 sentences)

Sequence

91825 reads, 270 reads per million, 128 experiments

uguuguCGGGUGGAUCACGAUGCAAUUUugaugaguaucauaggagaaaAAUUGCACGGUAUCCAUCUGUAaacc
.(((..(((((((((..((.(((((((((..................)))))))))))..)))))))))..))).

Structure

u   gu         CA  A         gaugagua 
 guu  CGGGUGGAU  CG UGCAAUUUu        u
 |||  |||||||||  || |||||||||         
 caa  GUCUACCUA  GC ACGUUAAaa        c
c   AU         UG  -         agaggaua 

Annotation confidence Medium

Genome context

chrX: 134169378-134169452 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-363

Disease association

hsa-mir-363 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-363-5p

• Accession: MIMAT0003385
• Description: Homo sapiens hsa-miR-363-5p mature miRNA
• Sequence: 7 - CGGGUGGAUCACGAUGCAAUUU - 28
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-363-3p

• Accession: MIMAT0000707
• Description: Homo sapiens hsa-miR-363-3p mature miRNA
• Sequence: 50 - AAUUGCACGGUAUCCAUCUGUA - 71
• Evidence: experimental ; array-cloned [1], cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267