Stem-loop hsa-mir-365b

Accession

MI0000769

Symbol

HGNC: MIR365B

Description

Homo sapiens hsa-mir-365b precursor miRNA mir-365

Gene
family

RF00659; mir-365

Literature search

61 open access papers mention hsa-mir-365b
(319 sentences)

Sequence

83122 reads, 1088 reads per million, 133 experiments

agaguguucaaggacagcaagaaaaaugAGGGACUUUCAGGGGCAGCUGUguuuucugacucagucaUAAUGCCCCUAAAAAUCCUUAUuguucuugcagugugcaucggg
...........(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))).))).)))))))).)))))))..))).)......

Structure

agaguguucaa g   --       a        AC   C       -----    U   u 
           g aca  gcaagaa aaugAGGG  UUU AGGGGCA     GCUG guu u
           | |||  ||||||| ||||||||  ||| |||||||     |||| |||  
           c ugu  cguucuu uUAUUCCU  AAA UCCCCGU     ugac cag c
-----gggcua g   ga       g        -A   A       AAUac    u   u 

Annotation confidence High

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR190. The sequence is unrelated to mammalian mir-190 (MIR:MI0000486).

Genome context

chr17: 31575411-31575521 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-365b

Disease association

hsa-mir-365b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-365b-5p

• Accession: MIMAT0022833
• Description: Homo sapiens hsa-miR-365b-5p mature miRNA
• Sequence: 29 - AGGGACUUUCAGGGGCAGCUGU - 50
• Evidence: experimental ; 454 [5]

Mature hsa-miR-365b-3p

• Accession: MIMAT0022834
• Description: Homo sapiens hsa-miR-365b-3p mature miRNA
• Sequence: 68 - UAAUGCCCCUAAAAAUCCUUAU - 89
• Evidence: experimental ; cloned [1,3-4], array-cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341


4. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


5. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345