miRBase entry: hsa-mir-365b

Stem-loop hsa-mir-365b

Homo sapiens hsa-mir-365b precursor miRNA
Gene family
MIPF0000061; mir-365

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR365B is a microRNA gene located within the NF1 microdeletion region, which is associated with neurofibromatosis type 1 (NF1) and tumorigenesis [PMC5370280]. Patients with NF1 microdeletions are hemizygous for MIR365B, along with other genes such as NF1, SUZ12, ATAD5, and MIR193A [PMC5370280]. The loss of MIR193A and MIR365B genes in patients with NF1 microdeletions may contribute to tumorigenesis in these individuals [PMC5370280]. While the role of SUZ12 loss in malignant peripheral nerve sheath tumor (MPNST) progression is well-documented, less is known about the involvement of ATAD5, MIR193A, and MIR365B in MPNST pathogenesis [PMC5370280]. The 1.4-Mb NF1 microdeletion region contains four microRNA genes: MIR193A, MIR365B, MIR4725, and MIR4733 [PMC5370280]. RT-qPCR analysis has been performed to study gene expression using TaqMan assays for validation purposes [PMC8278229]. Several miRNAs including miR-4262, miR-506-3p, and MIR365B have been identified as tumor suppressors targeting GALNT4 [PMC8504460]. Drosha cleavage activity has been detected over intronic regions of genes such as CTDSP1 and long noncoding RNA (lncRNA)-derived genes like MIR193A and MIR365B using POINT-5 analysis [PMC8122139]. ATAD5 along with other genes like miR193A and miR365B have been identified as having tumor suppressor activity within the NF1 microdeletion region [PMC8395254].

Literature search
61 open access papers mention hsa-mir-365b
(319 sentences)


83123 reads, 1088 reads per million, 133 experiments

agaguguucaa g   --       a        AC   C       -----    U   u 
           g aca  gcaagaa aaugAGGG  UUU AGGGGCA     GCUG guu u
           | |||  ||||||| ||||||||  ||| |||||||     |||| |||  
           c ugu  cguucuu uUAUUCCU  AAA UCCCCGU     ugac cag c
-----gggcua g   ga       g        -A   A       AAUac    u   u 

Annotation confidence High
Do you think this miRNA is real?
Xie et al. [1] refer to this sequence by the internal identifier MIR190. The sequence is unrelated to mammalian mir-190 (MIR:MI0000486).

Genome context
chr17: 31575411-31575521 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-365b
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-365b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-365b-5p

Accession MIMAT0022833
Description Homo sapiens hsa-miR-365b-5p mature miRNA
Evidence experimental
454 [5]
Database links
Predicted targets

Mature hsa-miR-365b-3p

Accession MIMAT0022834
Description Homo sapiens hsa-miR-365b-3p mature miRNA
Evidence experimental
cloned [1,3-4], array-cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 19144710
    Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
    "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
    "J Virol (2009) 83:3333-3341

  4. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770

  5. PubMed ID: 15735639
    Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
    "Nature (2005) 434:338-345