Stem-loop hsa-mir-369

Accession

MI0000777

Symbol

HGNC: MIR369

Description

Homo sapiens hsa-mir-369 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR369 is a microRNA (miRNA) with a notable presence on chromosome 8, playing a significant role in various cellular processes [PMC4203128]. It has been implicated in enhancing the expression of PKM2, which is crucial for cell reprogramming, by stabilizing HNRNPA2B1 [PMC7780020]. Additionally, MIR369 has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells by directly targeting ZEB1 [PMC8040887]. It is regulated by FUS3, but it is not explicitly stated to be part of the miR655 miRNA cluster [PMC4162360]. MIR369 also plays a role in enhancing reprogramming efficiency either alone or in combination with other miRNAs and can replace traditional nuclear reprogramming factors [PMC5951134]. It targets genes involved in stomatal movement and grain length regulation and responds to environmental stress such as Cadmium exposure [PMC8233840], [PMC5440550]. High expression of MIR369 is observed in pluripotent embryonic stem cells (ESCs), and this decreases upon differentiation; its coding region retains bivalent chromatin status which can change during ESC differentiation, indicating its involvement in maintaining pluripotency and cellular reprogramming efficiency [PMC4503752].

Literature search

42 open access papers mention hsa-mir-369
(74 sentences)

Sequence

10585 reads, 70 reads per million, 125 experiments

uugaagggAGAUCGACCGUGUUAUAUUCGCuuuauugacuucgAAUAAUACAUGGUUGAUCUUUucucag
.(((.((((((((((((((((..((((((............))))))..)))))))))))))))).))).

Structure

u   a                UA      Cuuua 
 uga gggAGAUCGACCGUGU  UAUUCG     u
 ||| ||||||||||||||||  ||||||      
 acu uUUUCUAGUUGGUACA  AUAAgc     u
g   c                UA      uucag 

Annotation confidence Medium

Genome context

chr14: 101065598-101065667 [+]

Clustered miRNAs

9 other miRNAs are < 10 kb from hsa-mir-369

Disease association

hsa-mir-369 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-369-5p

• Accession: MIMAT0001621
• Description: Homo sapiens hsa-miR-369-5p mature miRNA
• Sequence: 9 - AGAUCGACCGUGUUAUAUUCGC - 30
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-369-3p

• Accession: MIMAT0000721
• Description: Homo sapiens hsa-miR-369-3p mature miRNA
• Sequence: 44 - AAUAAUACAUGGUUGAUCUUU - 64
• Evidence: experimental ; cloned [1-4]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267