Stem-loop hsa-mir-378a

Accession

MI0000786

Symbol

HGNC: MIR378A

Description

Homo sapiens hsa-mir-378a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-378, a microRNA, is located on chromosome 5q32 and is variably annotated as MIR-378, MIR 378, miRNA378, hsa-mir-378, and hsa-mir-378a [PMC8071157]. The results from various programs have identified potential targets of hsa-mir-378 and another microRNA, hsa-miR-1827; these findings were consolidated using the Venny v2.1 online tool [PMC5771341].

Literature search

212 open access papers mention hsa-mir-378a
(1262 sentences)

Sequence

5214207 reads, 4812 reads per million, 154 experiments

agggCUCCUGACUCCAGGUCCUGUGUguuaccuagaaauagcACUGGACUUGGAGUCAGAAGGCcu
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))

Structure

   g  C              U    gu acc 
agg CU CUGACUCCAGGUCC GUGU  u   u
||| || |||||||||||||| ||||  |    
ucC GA GACUGAGGUUCAGG CAcg  a   a
   G  A              U    au aag 

Annotation confidence High

Comments

miR-422b was the most abundant miRNA cloned from human promyelocytic leukemia (HL-60) cells [2]. The sequence originates from the opposite arm of the human homologue of previously identified mouse mir-378 [1]. Landgraf et al. show that the 3' product (previously called miR-422b) is the predominant one [3]. Further, mir-378 and mir-422a loci are unrelated. miR-422b is thus renamed miR-378 here.

Genome context

chr5: 149732825-149732890 [+]

Disease association

hsa-mir-378a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-378a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-378a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-378a-5p

• Accession: MIMAT0000731
• Description: Homo sapiens hsa-miR-378a-5p mature miRNA
• Sequence: 5 - CUCCUGACUCCAGGUCCUGUGU - 26
• Evidence: experimental ; cloned [3]

Mature hsa-miR-378a-3p

• Accession: MIMAT0000732
• Description: Homo sapiens hsa-miR-378a-3p mature miRNA
• Sequence: 43 - ACUGGACUUGGAGUCAGAAGGC - 64
• Evidence: experimental ; cloned [2-3], Northern [2]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230