Stem-loop hsa-mir-379

Accession

MI0000787

Symbol

HGNC: MIR379

Description

Homo sapiens hsa-mir-379 precursor miRNA mir-379

Gene
family

RF04292; mir-379

Literature search

48 open access papers mention hsa-mir-379
(227 sentences)

Sequence

93096 reads, 109 reads per million, 119 experiments

agagaUGGUAGACUAUGGAACGUAGGcguuaugauuucugaccUAUGUAACAUGGUCCACUAACUcu
((((.((((.(((((((..(((((((((..........)).)))))))..))))))).)))).))))

Structure

    a    A       GA       -  uuau 
agag UGGU GACUAUG  ACGUAGG cg    g
|||| |||| |||||||  ||||||| ||     
ucUC AUCA CUGGUAC  UGUAUcc gu    a
    A    C       AA       a  cuuu 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr14: 101022066-101022132 [+]

Clustered miRNAs

11 other miRNAs are < 10 kb from hsa-mir-379

Disease association

hsa-mir-379 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-379-5p

• Accession: MIMAT0000733
• Description: Homo sapiens hsa-miR-379-5p mature miRNA
• Sequence: 6 - UGGUAGACUAUGGAACGUAGG - 26
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-379-3p

• Accession: MIMAT0004690
• Description: Homo sapiens hsa-miR-379-3p mature miRNA
• Sequence: 44 - UAUGUAACAUGGUCCACUAACU - 65
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


3. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267