Stem-loop hsa-mir-381

Accession

MI0000789

Symbol

HGNC: MIR381

Description

Homo sapiens hsa-mir-381 precursor miRNA

Literature search

72 open access papers mention hsa-mir-381
(408 sentences)

Sequence

11272 reads, 24 reads per million, 108 experiments

uacuuaaAGCGAGGUUGCCCUUUGUAUAUucgguuuauugacauggaaUAUACAAGGGCAAGCUCUCUGUgagua
((((((.((.(((.((((((((.((((((((.((........)).)))))))))))))))).))).)).))))))

Structure

      a  C   G        U        g  uua 
uacuua AG GAG UUGCCCUU GUAUAUuc gu   u
|||||| || ||| |||||||| |||||||| ||    
augagU UC CUC AACGGGAA CAUAUaag ua   u
      G  U   G        -        g  cag 

Annotation confidence High

Genome context

chr14: 101045920-101045994 [+]

Clustered miRNAs

18 other miRNAs are < 10 kb from hsa-mir-381

Disease association

hsa-mir-381 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-381-3p

• Accession: MIMAT0000736
• Description: Homo sapiens hsa-miR-381-3p mature miRNA
• Sequence: 49 - UAUACAAGGGCAAGCUCUCUGU - 70
• Evidence: experimental ; cloned [1-2], SOLiD [3]

Mature hsa-miR-381-5p

• Accession: MIMAT0022862
• Description: Homo sapiens hsa-miR-381-5p mature miRNA
• Sequence: 8 - AGCGAGGUUGCCCUUUGUAUAU - 29
• Evidence: experimental ; SOLiD [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


3. PubMed ID: 22282338
   Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
   "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
   "RNA (2012) 18:472-484