miRBase entry: hsa-mir-330

Stem-loop hsa-mir-330

Homo sapiens hsa-mir-330 precursor miRNA
Gene family
MIPF0000200; mir-330

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR330 is a microRNA that has been studied in various contexts. It has been found to be negatively associated with certain ALM components and HLA regulatory factors, such as TAP1, TAP2, CIITA, NLRC5, IRF1, and IRF8 [PMC8393554]. In the context of pancreatic diseases, MIR330 has shown differential expression between chronic pancreatitis patients and pancreatic ductal adenocarcinoma (PDAC) patients [PMC9599289]. It is upregulated in PDAC compared to immortalized pancreatic duct models [PMC9599289]. MIR330 is also associated with alterations in PDAC patients and may be a potential marker for PDAC detection [PMC9599289]. In the context of S. aureus infection, MIR330 expression increases rapidly and contributes to the loss of barrier integrity through down-regulation of ADAM19 and VE-Cadherin [PMC6165832]. The downregulation of MIR330 may also sustain epithelial-mesenchymal transition (EMT) through dysregulation of the RKIP network [PMC9600137]. Additionally, MIR330 has been observed in breast cancer cell lines and is associated with the regulation of target genes in luminal-A subtypes [PMC8261273]. It may also play a role in liver cancer development for chronic hepatitis B patients [PMC9946971]. Furthermore, MIR330 has been implicated in post-myocardial infarction heart failure (HF) and may be a candidate biomarker for HF progression after myocardial infarction [PMC8687817]. It has also shown potential therapeutic effects in acute coronary syndrome by suppressing plaque formation through the WNT signaling pathway [PMC8687817] and stable carotid plaques by targeting Talin-1 in symptomatic carotid stenosis patients [PMC8687817]. Additionally, MIR330 has been shown to inhibit oxidative stress damage in Alzheimer's disease mice and alleviate mitochondrial dysfunction [PMC7249309].

Literature search
48 open access papers mention hsa-mir-330
(282 sentences)


54219 reads, 414 reads per million, 149 experiments

cuuu   -  u a           --    -    U   AG    ugcaa 
    ggc ga c cugccUCUCUG  GGCC UGUG CUU  GCuc     g
    ||| || | |||||||||||  |||| |||| |||  ||||     a
    ccg cu g gacggAGAGAC  CCGG ACAC GAA  CGag     u
---c   u  c c           GU    C    -   -A    ccaac 

Annotation confidence High
Do you think this miRNA is real?
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context
chr19: 45638994-45639087 [-]

Database links

Mature hsa-miR-330-5p

Accession MIMAT0004693
Description Homo sapiens hsa-miR-330-5p mature miRNA
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-330-3p

Accession MIMAT0000751
Description Homo sapiens hsa-miR-330-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  4. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365