Accession
MI0000803
Symbol
HGNC:
MIR330
Description
Homo sapiens
hsa-mir-330 precursor miRNA mir-330
Gene
family?
family?
RF00770;
mir-330
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR330 is a microRNA that has been studied in various contexts. It has been found to be negatively associated with certain ALM components and HLA regulatory factors, such as TAP1, TAP2, CIITA, NLRC5, IRF1, and IRF8 [PMC8393554]. In the context of pancreatic diseases, MIR330 has shown differential expression between chronic pancreatitis patients and pancreatic ductal adenocarcinoma (PDAC) patients [PMC9599289]. It is upregulated in PDAC compared to immortalized pancreatic duct models [PMC9599289]. MIR330 is also associated with alterations in PDAC patients and may be a potential marker for PDAC detection [PMC9599289]. In the context of S. aureus infection, MIR330 expression increases rapidly and contributes to the loss of barrier integrity through down-regulation of ADAM19 and VE-Cadherin [PMC6165832]. The downregulation of MIR330 may also sustain epithelial-mesenchymal transition (EMT) through dysregulation of the RKIP network [PMC9600137]. Additionally, MIR330 has been observed in breast cancer cell lines and is associated with the regulation of target genes in luminal-A subtypes [PMC8261273]. It may also play a role in liver cancer development for chronic hepatitis B patients [PMC9946971]. Furthermore, MIR330 has been implicated in post-myocardial infarction heart failure (HF) and may be a candidate biomarker for HF progression after myocardial infarction [PMC8687817]. It has also shown potential therapeutic effects in acute coronary syndrome by suppressing plaque formation through the WNT signaling pathway [PMC8687817] and stable carotid plaques by targeting Talin-1 in symptomatic carotid stenosis patients [PMC8687817]. Additionally, MIR330 has been shown to inhibit oxidative stress damage in Alzheimer's disease mice and alleviate mitochondrial dysfunction [PMC7249309].
Literature search
48 open access papers mention hsa-mir-330
(282 sentences)
(282 sentences)
Sequence
54219
reads,
414
reads per million, 149 experiments
cuuuggcgaucacugccUCUCUGGGCCUGUGUCUUAGGCucugcaagaucaaccgaGCAAAGCACACGGCCUGCAGAGAggcagcgcucugccc
....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).))).
....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).))).
Structure
cuuu - u a -- - U AG ugcaa
ggc ga c cugccUCUCUG GGCC UGUG CUU GCuc g
||| || | ||||||||||| |||| |||| ||| |||| a
ccg cu g gacggAGAGAC CCGG ACAC GAA CGag u
---c u c c GU C - -A ccaac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].
Genome context
chr19: 45638994-45639087 [-]
Database links
Mature hsa-miR-330-5p
| Accession | MIMAT0004693 |
| Description | Homo sapiens hsa-miR-330-5p mature miRNA |
| Sequence | 18 - UCUCUGGGCCUGUGUCUUAGGC - 39 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-330-3p
| Accession | MIMAT0000751 |
| Description | Homo sapiens hsa-miR-330-3p mature miRNA |
| Sequence | 57 - GCAAAGCACACGGCCUGCAGAGA - 79 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
|
