Accession
MI0000803
Symbol
HGNC:
MIR330
Description
Homo sapiens
hsa-mir-330 precursor miRNA mir-330
Gene
family?
family?
RF00770;
mir-330
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR330 is a microRNA that has been identified as having a negative association with the ALM components TAP1 and TAP2, as well as HLA regulatory factors, suggesting a potential regulatory role in immune responses [PMC8393554]. It is differentially expressed in chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC), with an overexpression in PDAC compared to an immortalized pancreatic duct model [PMC9599289]. MIR330 is also upregulated in PDAC when compared to pancreatitis [PMC9599289]'>PMC9599289], and alterations in MIR330 have been observed across a significant portion of PDAC patients, indicating its potential as a biomarker for PDAC detection [PMC9599289]. Furthermore, MIR330 has been implicated in the loss of endothelial barrier integrity through its role in the down-regulation of ADAM19 and subsequent decrease of VE-Cadherin [PMC6165832]. It may also contribute to epithelial-mesenchymal transitions (EMT) through the dysregulation of the RKIP network [PMC9600137], and its expression has been observed across various cancer cell lines, suggesting a broader role in cancer biology [PMC8261273]. Additionally, MIR330 may have implications for chronic hepatitis B progression to liver cancer and has been linked with long non-coding RNA SNHG8 through trans-eQTL effects [PMC9946971; PMC7387553]..
Literature search
48 open access papers mention hsa-mir-330
(282 sentences)
(282 sentences)
Sequence
54219
reads,
414
reads per million, 149 experiments
cuuuggcgaucacugccUCUCUGGGCCUGUGUCUUAGGCucugcaagaucaaccgaGCAAAGCACACGGCCUGCAGAGAggcagcgcucugccc
....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).))).
....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).))).
Structure
cuuu - u a -- - U AG ugcaa
ggc ga c cugccUCUCUG GGCC UGUG CUU GCuc g
||| || | ||||||||||| |||| |||| ||| |||| a
ccg cu g gacggAGAGAC CCGG ACAC GAA CGag u
---c u c c GU C - -A ccaac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].
Genome context
chr19: 45638994-45639087 [-]
Database links
Mature hsa-miR-330-5p
| Accession | MIMAT0004693 |
| Description | Homo sapiens hsa-miR-330-5p mature miRNA |
| Sequence | 18 - UCUCUGGGCCUGUGUCUUAGGC - 39 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-330-3p
| Accession | MIMAT0000751 |
| Description | Homo sapiens hsa-miR-330-3p mature miRNA |
| Sequence | 57 - GCAAAGCACACGGCCUGCAGAGA - 79 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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