Accession
MI0000805
Symbol
HGNC:
MIR342
Description
Homo sapiens
hsa-mir-342 precursor miRNA mir-342
Gene
family?
family?
RF00760;
mir-342
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR342 is a microRNA that plays a role in regulating gene expression within cells [PMC4133867]. In MIR342 (-/-) mice, a decrease in the activation of NPY+pSTAT3+ neurons was observed, alongside an increase in POMC+pSTAT3+ neurons [PMC8437242]. These changes were associated with a decrease in food intake and an improvement in metabolic phenotypes, suggesting that MIR342 may have a role in energy balance and metabolism [PMC8437242]. Additionally, the downregulation of DNA-methyltransferase-1 (DNMT1) and subsequent reactivation of ADAM23 is linked to the restoration of proper MIR342 expression levels [PMC4133867]. This indicates that MIR342 may also be involved in epigenetic regulation through its influence on DNA methylation processes [PMC4133867].
Literature search
127 open access papers mention hsa-mir-342
(846 sentences)
(846 sentences)
Sequence
187586
reads,
524
reads per million, 134 experiments
gaaacugggcucaaggugAGGGGUGCUAUCUGUGAUUGAgggacaugguuaauggaauugUCUCACACAGAAAUCGCACCCGUcaccuuggccuacuua
.....(((((.((((((((.((((((..((((((..(((((.((((.....)))....).)))))))))))....)))))).)))))))))))))....
.....(((((.((((((((.((((((..((((((..(((((.((((.....)))....).)))))))))))....)))))).)))))))))))))....
Structure
gaaac u G --UA AU g ---- g
ugggc caaggugA GGGUGC UCUGUG UGAgg a cau g
||||| |||||||| |||||| |||||| ||||| | ||| u
auccg guuccacU CCCACG AGACAC ACUCU u gua u
-auuc - G CUAA -- g uaag a
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
This sequence was predicted by homology to a rat miRNA [1,2] and later verified in human [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr14: 100109655-100109753 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-342
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-342 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-342-5p
| Accession | MIMAT0004694 |
| Description | Homo sapiens hsa-miR-342-5p mature miRNA |
| Sequence | 19 - AGGGGUGCUAUCUGUGAUUGA - 39 |
| Evidence |
experimental
cloned [3-5], Northern [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-342-3p
| Accession | MIMAT0000753 |
| Description | Homo sapiens hsa-miR-342-3p mature miRNA |
| Sequence | 61 - UCUCACACAGAAAUCGCACCCGU - 83 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
References
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