Stem-loop hsa-mir-323a

Accession

MI0000807

Symbol

HGNC: MIR323A

Description

Homo sapiens hsa-mir-323a precursor miRNA

Literature search

45 open access papers mention hsa-mir-323a
(107 sentences)

Sequence

2423 reads, 46 reads per million, 60 experiments

uugguacuuggagagAGGUGGUCCGUGGCGCGUUCGCuuuauuuauggcgCACAUUACACGGUCGACCUCUuugcaguaucuaauc
..((((((.(.((((((((.(.(((((..(.((.((((........)))).)).)..))))).).)))))))).))))))).....

Structure

---uu      u g        G U     GC C  U    uua 
     gguacu g agagAGGU G CCGUG  G GU CGCu   u
     |||||| | |||||||| | |||||  | || ||||    
     cuauga c uuUCUCCA C GGCAC  U CA gcgg   u
cuaau      - g        G U     AU A  C    uau 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context

chr14: 101025732-101025817 [+]

Clustered miRNAs

12 other miRNAs are < 10 kb from hsa-mir-323a

Mature hsa-miR-323a-5p

• Accession: MIMAT0004696
• Description: Homo sapiens hsa-miR-323a-5p mature miRNA
• Sequence: 16 - AGGUGGUCCGUGGCGCGUUCGC - 37
• Evidence: experimental ; cloned [3]

Mature hsa-miR-323a-3p

• Accession: MIMAT0000755
• Description: Homo sapiens hsa-miR-323a-3p mature miRNA
• Sequence: 51 - CACAUUACACGGUCGACCUCU - 71
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


3. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365