Stem-loop hsa-mir-135b

Accession

MI0000810

Symbol

HGNC: MIR135B

Description

Homo sapiens hsa-mir-135b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR135B, a microRNA, was found to be downregulated in PWS INS-1 cell lines, alongside Mir3065 and Mir212 [PMC10138222]. This downregulation was observed despite the absence of differentially expressed genes (DEGs) in the RNA-seq data for predicted targets [PMC10138222]. In a separate study, MIR135B has been implicated in the regulation of the adenomatous polyposis coli (APC) gene by binding to its 3’UTR transcript [PMC3843547]. This interaction influences APC mRNA levels and thus modulates the Wnt signaling pathway, which is crucial for cell proliferation control [PMC3843547].

Literature search

190 open access papers mention hsa-mir-135b
(898 sentences)

Sequence

4823 reads, 126 reads per million, 76 experiments

cacucugcuguggccUAUGGCUUUUCAUUCCUAUGUGAuugcugucccaaacucAUGUAGGGCUAAAAGCCAUGGGcuacagugaggggcgagcucc
..(((((((((((((((((((((((...(((((((((((((......)))..))))))))))..))))))))))))))))))).)))).........

Structure

-------ca    -                   CAU          --   cu 
         cucu gcuguggccUAUGGCUUUU   UCCUAUGUGA  uug  g
         |||| |||||||||||||||||||   ||||||||||  |||   
         ggga ugacaucGGGUACCGAAAA   GGGAUGUAcu  aac  u
ccucgagcg    g                   -UC          ca   cc 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context

chr1: 205448302-205448398 [-]

Disease association

hsa-mir-135b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-135b-5p

• Accession: MIMAT0000758
• Description: Homo sapiens hsa-miR-135b-5p mature miRNA
• Sequence: 16 - UAUGGCUUUUCAUUCCUAUGUGA - 38
• Evidence: experimental ; cloned [3-4]

Mature hsa-miR-135b-3p

• Accession: MIMAT0004698
• Description: Homo sapiens hsa-miR-135b-3p mature miRNA
• Sequence: 55 - AUGUAGGGCUAAAAGCCAUGGG - 76
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365