Stem-loop hsa-mir-148b

Accession

MI0000811

Symbol

HGNC: MIR148B

Description

Homo sapiens hsa-mir-148b precursor miRNA mir-148

Gene
family

RF00248; mir-148

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR148B is a microRNA that is downregulated in breast cancer cases compared to controls [PMC9967215]. In a study, the ratio of MIR148B concentrations was found to be downregulated in breast cancer cases compared to controls [PMC9967215]. Additionally, MIR148B was found to be able to downregulate ACVR1/Alk-2 expression [PMC3515447]. The study also found that MIR21, MIR155, MIR10b, MIR373, MIR652, MIR425, and MIR29a showed coherent direction of ratio in breast cancer cases versus controls [PMC9967215]. However, the effect of mir26a on ACVR1/Alk-2 expression was unexpectedly positive [PMC3515447]. These findings suggest that the dysregulation of microRNAs such as MIR148B may play a role in breast cancer development and progression. Further research is needed to fully understand the mechanisms and potential therapeutic implications of these microRNAs in breast cancer.

Literature search

150 open access papers mention hsa-mir-148b
(777 sentences)

Sequence

274413 reads, 1329 reads per million, 151 experiments

caagcacgauuagcauuugaggugAAGUUCUGUUAUACACUCAGGCuguggcucucugaaagUCAGUGCAUCACAGAACUUUGUcucgaaagcuuucua
.......((..(((.((((((((((((((((((.((.((((..((((.............)))))))).)).)))))))))))))))))).))).))..

Structure

caagcac  uu   a                  U  A    CA    guggc 
       ga  agc uuugaggugAAGUUCUGU AU CACU  GGCu     u
       ||  ||| |||||||||||||||||| || ||||  ||||     c
       cu  ucg aagcucUGUUUCAAGACA UA GUGA  CUga     u
-----au  -u   a                  C  C    --    aaguc 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2]. Its expression was later verified in human [3,4].

Genome context

chr12: 54337216-54337314 [+]

Disease association

hsa-mir-148b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-148b-5p

• Accession: MIMAT0004699
• Description: Homo sapiens hsa-miR-148b-5p mature miRNA
• Sequence: 25 - AAGUUCUGUUAUACACUCAGGC - 46
• Evidence: experimental ; cloned [3]

Mature hsa-miR-148b-3p

• Accession: MIMAT0000759
• Description: Homo sapiens hsa-miR-148b-3p mature miRNA
• Sequence: 63 - UCAGUGCAUCACAGAACUUUGU - 84
• Evidence: experimental ; cloned [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365