Accession
MI0000813
Symbol
HGNC:
MIR324
Description
Homo sapiens
hsa-mir-324 precursor miRNA mir-324
Gene
family?
family?
RF03479;
mir-324
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR324 is a microRNA that has been associated with adrenergic trans-differentiation of sensory nerves in mouse models of oral cancer [PMC7396546]. The regulatory regions of murine MIR324 have been found to contain a TonE consensus sequence, suggesting that TonEBP may regulate the expression of this microRNA [PMC9104010]. The removal of MIR324 in mice has been shown to result in hippocampal hyperexcitability and an increase in epilepsy-associated events [PMC8129095]. Additionally, the removal of MIR324 has been found to significantly alter the expression of genes in the hippocampus and neocortex [PMC8129095]. Mice lacking MIR324 have also been found to exhibit an increase in hyperexcitable epilepsy-related events [PMC8129095]. The expression levels of MIR324 have been shown to be altered with age and sex, with many key miRNAs, including miR-34a, being upregulated in the ageing brain and showing differential expression by sex [PMC8129095]. Furthermore, high expression levels of MIR324 have been associated with better prognosis in breast cancer patients [PMC8648947]. It has also been suggested that further investigation into the downstream effects of MIR324 removal may reveal novel pathways involved in certain conditions such as ISOD and PPDE [PMC8129095]. Overall, understanding the role and regulation of MIR324 may provide insights into various biological processes and potential therapeutic targets.
Literature search
65 open access papers mention hsa-mir-324
(212 sentences)
(212 sentences)
Sequence
51358
reads,
516
reads per million, 148 experiments
cugacuaugccucccCGCAUCCCCUAGGGCAUUGGUGuaaagcuggagaCCCACUGCCCCAGGUGCUGCUGGggguuguaguc
..(((((((.(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).))))).)))))))
..(((((((.(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).))))).)))))))
Structure
cu c C U C A U U aaag gacuaug cuccc GCA C CCU GGGCA UGG Gu c ||||||| ||||| ||| | ||| ||||| ||| || cugaugu gggGG CGU G GGA CCCGU ACC Ca u -- u U C U C C - gagg
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr17: 7223297-7223379 [-]
Database links
Mature hsa-miR-324-5p
| Accession | MIMAT0000761 |
| Description | Homo sapiens hsa-miR-324-5p mature miRNA |
| Sequence | 16 - CGCAUCCCCUAGGGCAUUGGUG - 37 |
| Evidence |
experimental
cloned [4-5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-324-3p
| Accession | MIMAT0000762 |
| Description | Homo sapiens hsa-miR-324-3p mature miRNA |
| Sequence | 50 - CCCACUGCCCCAGGUGCUGCUGG - 72 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
|
| Predicted targets |
|
References
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