Accession
MI0000813
Symbol
HGNC:
MIR324
Description
Homo sapiens
hsa-mir-324 precursor miRNA mir-324
Gene
family?
family?
RF03479;
mir-324
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR324 is a microRNA encoded by the MIR324 gene located on chromosome 17p13.1 in humans [PMC9399342]. In murine models, MIR324 has been implicated in the adrenergic trans-differentiation of sensory nerves in oral cancer models, particularly upon the loss of TP53 [PMC7396546]. The expression of MIR324 is regulated by TonEBP, as suggested by the identification of a TonE consensus sequence in its regulatory regions [PMC9104010]. The absence of MIR324 has been confirmed in miR-324-null mice using qRT-PCR, which also revealed a lack of expression in the hippocampus and neocortex [PMC8129095]. This deficiency leads to hippocampal hyperexcitability and an increase in epilepsy-associated events [PMC8129095]'>PMC8129095], with further research needed to determine if cognitive dysfunction also occurs as a result [PMC8129095]. The removal of MIR324 results in significant differential expression (DE) of genes associated with epilepsy and cognitive dysfunction, suggesting potential novel pharmaceutical targets for these conditions could be identified through further investigation into its downstream effects [PMC8129095]. Additionally, high expression levels of MIR324 have been associated with better prognosis for breast cancer patients, indicating its potential as a prognostic biomarker [PMC8648947].
Literature search
65 open access papers mention hsa-mir-324
(212 sentences)
(212 sentences)
Sequence
51358
reads,
516
reads per million, 148 experiments
cugacuaugccucccCGCAUCCCCUAGGGCAUUGGUGuaaagcuggagaCCCACUGCCCCAGGUGCUGCUGGggguuguaguc
..(((((((.(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).))))).)))))))
..(((((((.(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).))))).)))))))
Structure
cu c C U C A U U aaag gacuaug cuccc GCA C CCU GGGCA UGG Gu c ||||||| ||||| ||| | ||| ||||| ||| || cugaugu gggGG CGU G GGA CCCGU ACC Ca u -- u U C U C C - gagg
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr17: 7223297-7223379 [-]
Database links
Mature hsa-miR-324-5p
| Accession | MIMAT0000761 |
| Description | Homo sapiens hsa-miR-324-5p mature miRNA |
| Sequence | 16 - CGCAUCCCCUAGGGCAUUGGUG - 37 |
| Evidence |
experimental
cloned [4-5] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-324-3p
| Accession | MIMAT0000762 |
| Description | Homo sapiens hsa-miR-324-3p mature miRNA |
| Sequence | 50 - CCCACUGCCCCAGGUGCUGCUGG - 72 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
|
| Predicted targets |
|
References
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