Accession
MI0000814
Symbol
HGNC:
MIR338
Description
Homo sapiens
hsa-mir-338 precursor miRNA mir-338
Gene
family?
family?
RF00686;
mir-338
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR338 is a microRNA that plays a role in the osteoblast lineage priming ability of bone marrow stromal cells, as revealed by single-cell transcriptomic analysis [PMC9898552]. The conditional knockdown of the MIR338 cluster in the preosteoblast lineage further confirmed its role in restoring this priming ability [PMC9898552]. In the context of hepatocellular carcinoma (HCC), a comprehensive search was conducted to determine the diagnostic value of miR-338-5p [PMC5783480]. The search included databases such as Gene Expression Omnibus (GEO), PubMed, Embase, Cochrane, Web of Science, Sinomed, Chinese VIP, Wanfang database, and China National Knowledge Infrastructure (CNKI) [PMC5783480]. The search strategy included terms related to miR-338 and HCC to identify relevant studies [PMC5783480]. This search was conducted until December 15, 2016 [PMC5783480]. The aim was to gather comprehensive data on the diagnostic value of miR-338-5p in HCC [PMC5783480].
Literature search
96 open access papers mention hsa-mir-338
(715 sentences)
(715 sentences)
Sequence
65923
reads,
385
reads per million, 148 experiments
ucuccAACAAUAUCCUGGUGCUGAGUGaugacucaggcgacUCCAGCAUCAGUGAUUUUGUUGaaga
(((.((((((.(((((((((((((((.............))).))))))))).))).)))))).)))
(((.((((((.(((((((((((((((.............))).))))))))).))).)))))).)))
Structure
c U - - Gauga ucu cAACAA AUC CUGGUGCUG AGU c ||| |||||| ||| ||||||||| ||| u aga GUUGUU UAG GACUACGAC Uca c a U U C gcgga
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr17: 81125883-81125949 [-]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-338
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-338 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-338-5p
| Accession | MIMAT0004701 |
| Description | Homo sapiens hsa-miR-338-5p mature miRNA |
| Sequence | 6 - AACAAUAUCCUGGUGCUGAGUG - 27 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-338-3p
| Accession | MIMAT0000763 |
| Description | Homo sapiens hsa-miR-338-3p mature miRNA |
| Sequence | 42 - UCCAGCAUCAGUGAUUUUGUUG - 63 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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