Stem-loop hsa-mir-339

Accession

MI0000815

Symbol

HGNC: MIR339

Description

Homo sapiens hsa-mir-339 precursor miRNA mir-339

Gene
family

RF00763; mir-339

Literature search

58 open access papers mention hsa-mir-339
(200 sentences)

Sequence

53274 reads, 283 reads per million, 130 experiments

cggggcggccgcucUCCCUGUCCUCCAGGAGCUCACGugugccugccugUGAGCGCCUCGACGACAGAGCCGgcgccugccccagugucugcgc
.(((((((.((((..(.(((((.((.(((.(((((((.((....)).))))))).))).)).))))).)..)))).)))))))...........

Structure

----------c       c    cU C     C  C   A       u  g 
           ggggcgg cgcu  C CUGUC UC AGG GCUCACG gu c
           ||||||| ||||  | ||||| || ||| ||||||| ||  
           ccccguc gcgG  G GACAG AG UCC CGAGUgu cg c
cgcgucuguga       c    CC A     C  C   G       c  u 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,3]. Expression of mature miRNA was later verified in human [2,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr7: 1022933-1023026 [-]

Disease association

hsa-mir-339 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-339-5p

• Accession: MIMAT0000764
• Description: Homo sapiens hsa-miR-339-5p mature miRNA
• Sequence: 15 - UCCCUGUCCUCCAGGAGCUCACG - 37
• Evidence: experimental ; cloned [2,4]

Mature hsa-miR-339-3p

• Accession: MIMAT0004702
• Description: Homo sapiens hsa-miR-339-3p mature miRNA
• Sequence: 50 - UGAGCGCCUCGACGACAGAGCCG - 72
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365