Stem-loop hsa-mir-335

Accession

MI0000816

Symbol

HGNC: MIR335

Description

Homo sapiens hsa-mir-335 precursor miRNA mir-335

Gene
family

RF00766; mir-335

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR335 is a microRNA implicated in various cellular processes, and its deregulation has been observed in adipose-derived stem cells (ASCs) [PMC6053905]. This deregulation is associated with a disruption in the timely inactivation of the T gene, which is further linked to compromised lamin A interaction with the T locus, as evidenced by studies conducted on mutant induced pluripotent stem cells (iPS cells) [PMC6053905]. Additionally, MIR335 is among a group of microRNAs, including MIR24-2, MIR142, MIR490, and MIR296, that are present in extracellular vesicles (EVs) [PMC7287171]. These microRNAs are known to target genes that are predominantly involved in critical signaling and structural pathways within the cell such as "Ras protein signal transduction" and "Actin/microtubule cytoskeleton organization" [PMC7287171]. The presence of MIR335 within EVs suggests its potential role in intercellular communication and regulation of these pathways.

Literature search

169 open access papers mention hsa-mir-335
(872 sentences)

Sequence

142960 reads, 4193 reads per million, 137 experiments

uguuuugagcgggggUCAAGAGCAAUAACGAAAAAUGUuugucauaaaccgUUUUUCAUUAUUGCUCCUGACCuccucucauuugcuauauuca
.....((((.((((((((.(((((((((.((((((((.((......)).)))))))).))))))))).)))))))).)))).............

Structure

--------uguuu    c        A         C        U  gu 
             ugag gggggUCA GAGCAAUAA GAAAAAUG uu  c
             |||| |||||||| ||||||||| |||||||| ||   
             acuc ccuCCAGU CUCGUUAUU CUUUUUgc aa  a
acuuauaucguuu    u        C         A        c  au 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context

chr7: 130496111-130496204 [+]

Disease association

hsa-mir-335 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-335-5p

• Accession: MIMAT0000765
• Description: Homo sapiens hsa-miR-335-5p mature miRNA
• Sequence: 16 - UCAAGAGCAAUAACGAAAAAUGU - 38
• Evidence: experimental ; cloned [3-4]

Mature hsa-miR-335-3p

• Accession: MIMAT0004703
• Description: Homo sapiens hsa-miR-335-3p mature miRNA
• Sequence: 52 - UUUUUCAUUAUUGCUCCUGACC - 73
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365