Accession
MI0000822
Symbol
HGNC:
MIR133B
Description
Homo sapiens
hsa-mir-133b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR133B is a microRNA that has been studied in various contexts. In one study, it was found that the long non-coding RNA (lncRNA) LOC400043 interacts with MIR133B, leading to the downregulation of its expression [PMC7068214]. Another study demonstrated that the insertion of miRNA target sites for MIR133B and miR206 into the NP genome segment of influenza A virus effectively attenuated infection in murine myocyte-like cells and in the heart [PMC9094651]. In addition to these findings, other researchers have also investigated miRNAs in Parkinson's disease (PD) tissues, including MIR133B [PMC3540391]. Furthermore, the effect of intranasal delivery of MIR133B on functional recovery was assessed using two behavior tasks: GSM for forelimb grip strength evaluation and hanging task for forelimb grasp assessment post-spinal cord injury (SCI) [PMC10047048]. These studies highlight the importance of MIR133B in various biological processes and its potential therapeutic applications.
Literature search
328 open access papers mention hsa-mir-133b
(1862 sentences)
(1862 sentences)
Sequence
12384
reads,
266
reads per million, 108 experiments
ccucagaagaaagaugcccccugcucuggcuggucaaacggaaccaaguccgucuuccugagaggUUUGGUCCCCUUCAACCAGCUAcagcagggcuggcaaugcccaguccuuggaga
..............(((((((((((.((((((((..((.((.((((((.((.((((...)))))))))))).)).))..)))))))).)))))))..))))....(((.....)))...
..............(((((((((((.((((((((..((.((.((((((.((.((((...)))))))))))).)).))..)))))))).)))))))..))))....(((.....)))...
Structure
----ccucagaagaaaga -- c ca c a u g c
ugcc cccugcu uggcuggu aa gg accaag cc ucuu
|||| ||||||| |||||||| || || |||||| || |||| c
acgg gggacga AUCGACCA UU CC UGGUUU gg agag
agagguuccugacccgua uc c AC C C - - u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
miR-133b was predicted based on comparative analysis of human, mouse and Fugu [1], and later verified in human [2].
Genome context
chr6: 52148923-52149041 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-133b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-133b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-133b
| Accession | MIMAT0000770 |
| Description | Homo sapiens hsa-miR-133b mature miRNA |
| Sequence | 66 - UUUGGUCCCCUUCAACCAGCUA - 87 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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