Stem-loop rno-let-7e

Accession

MI0000832

Description

Rattus norvegicus rno-let-7e precursor miRNA

Gene family

MIPF0000002; let-7

Literature search

97 open access papers mention rno-let-7e
(581 sentences)

Sequence

496052 reads, 454 reads per million, 496 experiments

cgcgccccccgggcUGAGGUAGGAGGUUGUAUAGUUgaggaagacacccgaggagaucaCUAUACGGCCUCCUAGCUUUCCccaggcugcgcc
.((((..((.(((..(((.((((((((((((((((.((..................)))))))))))))))))).)))..))).))..)))).

Structure

c    cc  c   cU   G                U  ggaagaca 
 gcgc  cc ggg  GAG UAGGAGGUUGUAUAGU ga        c
 ||||  || |||  ||| |||||||||||||||| ||         
 cgcg  gg ccC  UUC AUCCUCCGGCAUAUCa cu        c
c    uc  a   CU   G                -  agaggagc 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr1: 59704381-59704473 [+]

Clustered miRNAs

3 other miRNAs are < 10 kb from rno-let-7e

Mature rno-let-7e-5p

• Accession: MIMAT0000777
• Description: Rattus norvegicus rno-let-7e-5p mature miRNA
• Sequence: 15 - UGAGGUAGGAGGUUGUAUAGUU - 36
• Evidence: experimental ; cloned [1-3], SOLiD [4]

Mature rno-let-7e-3p

• Accession: MIMAT0004706
• Description: Rattus norvegicus rno-let-7e-3p mature miRNA
• Sequence: 60 - CUAUACGGCCUCCUAGCUUUCC - 81
• Evidence: experimental ; cloned [3], SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


3. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


4. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249