Stem-loop rno-mir-221

Accession

MI0000961

Description

Rattus norvegicus rno-mir-221 precursor miRNA

Literature search

62 open access papers mention rno-mir-221
(303 sentences)

Sequence

321832 reads, 312 reads per million, 494 experiments

ugaauauccaggucuggggcaugaACCUGGCAUACAAUGUAGAUUUCuguguuuguuaggcaacAGCUACAUUGUCUGCUGGGUUUCaggcuaccuggaagcauuucuc
......(((((((....(((.(((((((((((.(((((((((....((((((((...)))).))))))))))))).))))))).)))).))))))))))..........

Structure

----ugaaua       cugg   a    -       U         AUUU    -    g 
          uccaggu    ggc ugaA CCUGGCA ACAAUGUAG    Cugu guuu  
          |||||||    ||| |||| ||||||| |||||||||    |||| |||| u
          aggucca    ucg aCUU GGGUCGU UGUUACAUC    GAca cgga  
cucuuuacga       ----   g    U       C         ----    a    u 

Annotation confidence High

Genome context

chrX: 3684480-3684588 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from rno-mir-221

Mature rno-miR-221-5p

• Accession: MIMAT0017163
• Description: Rattus norvegicus rno-miR-221-5p mature miRNA
• Sequence: 25 - ACCUGGCAUACAAUGUAGAUUUC - 47
• Evidence: experimental ; SOLiD [4]

Mature rno-miR-221-3p

• Accession: MIMAT0000890
• Description: Rattus norvegicus rno-miR-221-3p mature miRNA
• Sequence: 65 - AGCUACAUUGUCUGCUGGGUUUC - 87
• Evidence: experimental ; cloned [1-3], Northern [1], SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


4. PubMed ID: 17805466
   Cloning and identification of novel microRNAs from rat hippocampus
   "He X, Zhang Q, Liu Y, Pan X"
   "Acta Biochim Biophys Sin (Shanghai) (2007) 39:708-714