miRBase entry: ebv-mir-BHRF1-2

Stem-loop ebv-mir-BHRF1-2

Accession

MI0001065

Description

Epstein Barr virus ebv-mir-BHRF1-2 precursor miRNA

Sequence

cuuuuAAAUUCUGUUGCAGCAGAUAGCugauacccaauguUAUCUUUUGCGGCAGAAAUUGAaag
(((((((.(((((((((((.(((((((...........))))))).))))))))))).)))))))

Structure

       A           C       ugau 
cuuuuAA UUCUGUUGCAG AGAUAGC    a
||||||| ||||||||||| |||||||    c
gaaAGUU AAGACGGCGUU UCUAUug    c
       A           U       uaac

Annotation confidence Not enough data

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Comments

Pfeffer et al. cloned 5 miRNAs from a Burkitt's lymphoma cell line (BL41) infected with the B95-8 strain of Epstein-Barr virus [1]. They were all confirmed by Northern blot. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

HHV507799: 42848-42912 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from ebv-mir-BHRF1-2

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

ebv-mir-BHRF1-2 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature ebv-miR-BHRF1-2-5p

Accession	MIMAT0000996
Description	Epstein Barr virus ebv-miR-BHRF1-2-5p mature miRNA
Sequence	6 - AAAUUCUGUUGCAGCAGAUAGC - 27
Evidence	experimental cloned [1-2], Northern [1]

Mature ebv-miR-BHRF1-2-3p

Accession	MIMAT0000997
Description	Epstein Barr virus ebv-miR-BHRF1-2-3p mature miRNA
Sequence	41 - UAUCUUUUGCGGCAGAAAUUGA - 62
Evidence	experimental cloned [1-2], Northern [1]

References

PubMed ID: 17604727
A mammalian microRNA expression atlas based on small RNA library sequencing
"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
"Cell (2007) 129:1401-1414

PubMed ID: 15118162
Identification of virus-encoded microRNAs
"Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T"
"Science (2004) 304:734-736