Stem-loop ebv-mir-BHRF1-3

Accession

MI0001066

Description

Epstein Barr virus ebv-mir-BHRF1-3 precursor miRNA

Sequence

ucUAACGGGAAGUGUGUAAGCACAcacguaauuugcaagcggugcuucacgcucuucguuaaaau
..(((((((.((((((.((((((...(((.........))))))))))))))).)))))))....

Structure

--uc       A      U      Aca   aau 
    UAACGGG AGUGUG AAGCAC   cgu   u
    ||||||| |||||| ||||||   |||   u
    auugcuu ucgcac uucgug   gcg   g
uaaa       c      -      ---   aac 

Annotation confidence Not enough data

Comments

Pfeffer et al. cloned 5 miRNAs from a Burkitt's lymphoma cell line (BL41) infected with the B95-8 strain of Epstein-Barr virus [1]. They were all confirmed by Northern blot. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

HHV507799: 42966-43030 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from ebv-mir-BHRF1-3

Disease association

ebv-mir-BHRF1-3 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BHRF1-3

• Accession: MIMAT0000998
• Description: Epstein Barr virus ebv-miR-BHRF1-3 mature miRNA
• Sequence: 3 - UAACGGGAAGUGUGUAAGCACA - 24
• Evidence: experimental ; cloned [1-2], Northern [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15118162
   Identification of virus-encoded microRNAs
   "Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T"
   "Science (2004) 304:734-736