Stem-loop ebv-mir-BART1

Accession

MI0001067

Description

Epstein Barr virus ebv-mir-BART1 precursor miRNA

Sequence

gggggUCUUAGUGGAAGUGACGUGCUGUGaauacagguccaUAGCACCGCUAUCCACUAUGUCucgcccg
(((.(...(((((((((((..((((((((.((....)).)))))))))))).))))))).....).))).

Structure

-   g --UCU       -    AC        a  a 
 ggg g     UAGUGGA AGUG  GUGCUGUG au c
 ||| |     ||||||| ||||  |||||||| ||  
 ccc c     AUCACCU UCGC  CACGAUac ug a
g   g uCUGU       A    --        c  g 

Annotation confidence Not enough data

Comments

Pfeffer et al. cloned 5 miRNAs from a Burkitt's lymphoma cell line (BL41) infected with the B95-8 strain of Epstein-Barr virus [1]. They were all confirmed by Northern blot. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

HHV507799: 139346-139415 [+]

Clustered miRNAs

20 other miRNAs are < 10 kb from ebv-mir-BART1

Disease association

ebv-mir-BART1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BART1-5p

• Accession: MIMAT0000999
• Description: Epstein Barr virus ebv-miR-BART1-5p mature miRNA
• Sequence: 6 - UCUUAGUGGAAGUGACGUGCUGUG - 29
• Evidence: experimental ; cloned [1,3], Northern [1]

Mature ebv-miR-BART1-3p

• Accession: MIMAT0003390
• Description: Epstein Barr virus ebv-miR-BART1-3p mature miRNA
• Sequence: 42 - UAGCACCGCUAUCCACUAUGUC - 63
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15118162
   Identification of virus-encoded microRNAs
   "Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T"
   "Science (2004) 304:734-736


3. PubMed ID: 16557291
   Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
   Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR
   PLoS Pathog (2006) 2:e23