miRBase entry: hsa-mir-196b

Stem-loop hsa-mir-196b

Homo sapiens hsa-mir-196b precursor miRNA
Gene family
MIPF0000031; mir-196

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR196B is a microRNA that has been selected for further study [PMC4413621]. It is known to target HOXA5, along with miR196A [PMC3742271]. In the context of colorectal cancer, mRNA microarray analysis and bioinformatics tools were used to identify the target genes of MIR196B [PMC4413621]. Specifically, the study investigated whether MIR196B regulates FAS mRNA and protein levels in SW480 cells [PMC4413621].

Literature search
163 open access papers mention hsa-mir-196b
(815 sentences)


320705 reads, 1494 reads per million, 147 experiments

--     uc      uU       U  C           ucca 
  acugg  ggugau  AGGUAGU UC UGUUGUUGGGa    c
  |||||  ||||||  ||||||| || |||||||||||     
  ugacu  ucauua  UCCGUCA AG ACGACAGCUcu    c
gu     --      CU       C  C           cuuu 

Annotation confidence High
Do you think this miRNA is real?
miR-196b is predicted based on sequence homology to miR-196a [1]. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr7: 27169480-27169563 [-]

Disease association
hsa-mir-196b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-196b-5p

Accession MIMAT0001080
Description Homo sapiens hsa-miR-196b-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-196b-3p

Accession MIMAT0009201
Description Homo sapiens hsa-miR-196b-3p mature miRNA
Evidence experimental
454 [4]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 19144710
    Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
    "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
    "J Virol (2009) 83:3333-3341

  4. PubMed ID: 15105502
    MicroRNA-directed cleavage of HOXB8 mRNA
    "Yekta S, Shih IH, Bartel DP"
    "Science (2004) 304:594-596