Accession
MI0001150
Symbol
HGNC:
MIR196B
Description
Homo sapiens
hsa-mir-196b precursor miRNA
Gene family
MIPF0000031;
mir-196
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR196B is a microRNA that has been selected for further study [PMC4413621]. It is known to target HOXA5, along with miR196A [PMC3742271]. In the context of colorectal cancer, mRNA microarray analysis and bioinformatics tools were used to identify the target genes of MIR196B [PMC4413621]. Specifically, the study investigated whether MIR196B regulates FAS mRNA and protein levels in SW480 cells [PMC4413621].
Literature search
163 open access papers mention hsa-mir-196b
(815 sentences)
(815 sentences)
Sequence
320705
reads,
1494
reads per million, 147 experiments
acuggucggugauuUAGGUAGUUUCCUGUUGUUGGGauccaccuuucucUCGACAGCACGACACUGCCUUCauuacuucaguug
(((((..((((((..(((((((.((.(((((((((((..........))))))))))).)).)))))))..)))))))))))..
(((((..((((((..(((((((.((.(((((((((((..........))))))))))).)).)))))))..)))))))))))..
Structure
-- uc uU U C ucca acugg ggugau AGGUAGU UC UGUUGUUGGGa c ||||| |||||| ||||||| || ||||||||||| ugacu ucauua UCCGUCA AG ACGACAGCUcu c gu -- CU C C cuuu
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-196b is predicted based on sequence homology to miR-196a [1]. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr7: 27169480-27169563 [-]
Disease association
hsa-mir-196b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-196b-5p
| Accession | MIMAT0001080 |
| Description | Homo sapiens hsa-miR-196b-5p mature miRNA |
| Sequence | 15 - UAGGUAGUUUCCUGUUGUUGGG - 36 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-196b-3p
| Accession | MIMAT0009201 |
| Description | Homo sapiens hsa-miR-196b-3p mature miRNA |
| Sequence | 50 - UCGACAGCACGACACUGCCUUC - 71 |
| Evidence |
experimental
454 [4] |
| Database links |
|
| Predicted targets |
|
References
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