Accession
MI0001170
Description
Gallus gallus
gga-mir-33-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Gga-mir-33 is a microRNA found in chickens that plays a role in regulating fatty acid oxidation in the liver [PMC7936154]. It is homologous to gga-mir-33* [PMC3005926]. Studies have shown that gga-mir-33 targets enzymes involved in fatty acid oxidation, such as CROT, HADHB, and FTO [PMC7936154]. In the liver of newly hatched chicks subjected to a delay in feeding, the expression of gga-mir-33 is significantly lower compared to chicks that were fed from hatch [PMC7936154]. This suggests that gga-mir-33 may negatively regulate fatty acid oxidation when chicks rely on residual yolk lipids for energy production [PMC7936154'>PMC7936154]. The expression of gga-mir-33 increases from hatching through the first weeks of posthatch life [PMC7936154]. It has been predicted that gga-mir-33 targets various enzymes involved in metabolic signaling cascades and effector enzymes related to lipid metabolism [PMC7936154]. Gga-mir-33 has been found to regulate fat mass and obesity-associated (FTO) genes associated with obesity in chicken liver, similar to its function in mammals such as humans and mice [PMC7084605]. Studies have shown that gga-mir-33 is closely related to lipid metabolism and fatty acid oxidation by regulating FTO, CROT, and HADHB genes in chicken liver [PMC9714206]. Furthermore, gga-mir-33 and its host gene SREBF2 are highly expressed in the chicken liver, suggesting their involvement in upregulating genes related to cholesterol biosynthesis [PMC3675212].
Literature search
8 open access papers mention gga-mir-33-1
(121 sentences)
(121 sentences)
Sequence
24272
reads,
294
reads per million, 5 experiments
cuguaGUGCAUUGUAGUUGCAUUGCaugugcuggcaguaacugugcAAUGUUCCUGCAGUGCAGUAcag
(((((.((((((((((..(((((((((.((((...))))...)))))))))..)))))))))).)))))
(((((.((((((((((..(((((((((.((((...))))...)))))))))..)))))))))).)))))
Structure
G UU --g g
cugua UGCAUUGUAG GCAUUGCau ugcu
||||| |||||||||| ||||||||| |||| g
gacAU ACGUGACGUC UGUAAcgug auga
G CU uca c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr1: 49529873-49529941 [-]
Database links
Mature gga-miR-33-5p
| Accession | MIMAT0001100 |
| Description | Gallus gallus gga-miR-33-5p mature miRNA |
| Sequence | 6 - GUGCAUUGUAGUUGCAUUGC - 25 |
| Evidence |
experimental
cloned [1-2], Illumina [3] |
| Database links |
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| Predicted targets |
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Mature gga-miR-33-3p
| Accession | MIMAT0026490 |
| Description | Gallus gallus gga-miR-33-3p mature miRNA |
| Sequence | 47 - AAUGUUCCUGCAGUGCAGUA - 66 |
| Evidence |
experimental
Illumina [3] |
| Database links |
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| Predicted targets |
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References
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