Accession
MI0001448
Symbol
HGNC:
MIR425
Description
Homo sapiens
hsa-mir-425 precursor miRNA mir-425
Gene
family?
family?
RF00803;
mir-425
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR425 is a differentially expressed microRNA (miRNA) that has been studied in various biological contexts, including cancer and heart disease. In a study focusing on testicular development, MIR425 was among nine miRNAs selected for validation by RT-qPCR in calf and bull testes [PMC9777600]. It has been implicated in breast cancer, where it was found to be generally downregulated in serum samples [PMC9967215], and it is recognized as a regulator of tumorigenesis [PMC5361868]. MIR425 has also been associated with the regulation of the ubiquitin-like protein UBQLN1, although overexpression experiments did not show an effect on UBQLN1 levels [PMC5361868]. In genetic studies involving mice, homozygosity for a MIR425 deletion was found to be lethal, suggesting an essential role for this miRNA in development or survival [PMC8520725]. Furthermore, MIR425 is expressed in cumulus cells (CCs) and has been implicated as a potential biomarker for various cancers including cervical cancer and pancreatic ductal adenocarcinoma (PDAC) [PMC8316837; PMC9599289].. It also plays a role in the regulation of cardiac gene expression and may serve as an early biomarker for heart conditions such as hypertrophic cardiomyopathy and heart failure [PMC9897690; PMC8773242].. Lastly, MIR425 is considered among potential endogenous controls for gene expression studies involving whole blood samples due to its stable expression levels [PMC6172720].
Literature search
51 open access papers mention hsa-mir-425
(291 sentences)
(291 sentences)
Sequence
219172
reads,
790
reads per million, 150 experiments
gaaagcgcuuuggAAUGACACGAUCACUCCCGUUGAgugggcacccgagaagccAUCGGGAAUGUCGUGUCCGCCCagugcucuuuc
(((((.((.((((...(((((((.((.(((((....((((............))))))))).)))))))))...)))).)).)))))
(((((.((.((((...(((((((.((.(((((....((((............))))))))).)))))))))...)))).)).)))))
Structure
c u AAU U C UUGA gcacc
gaaag gc uugg GACACGA CA UCCCG gugg c
||||| || |||| ||||||| || ||||| ||||
cuuuc cg gaCC CUGUGCU GU AGGGC UAcc g
u u CGC - A ---- gaaga
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
The mature sequences were previously named miR-425-5p and miR-425-3p in [2] and here. Landgraf et al. show that the 5' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr3: 49020148-49020234 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-425
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-425 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-425-5p
| Accession | MIMAT0003393 |
| Description | Homo sapiens hsa-miR-425-5p mature miRNA |
| Sequence | 14 - AAUGACACGAUCACUCCCGUUGA - 36 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-425-3p
| Accession | MIMAT0001343 |
| Description | Homo sapiens hsa-miR-425-3p mature miRNA |
| Sequence | 55 - AUCGGGAAUGUCGUGUCCGCCC - 76 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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