Stem-loop hsa-mir-425

Accession

MI0001448

Symbol

HGNC: MIR425

Description

Homo sapiens hsa-mir-425 precursor miRNA mir-425

Gene
family

RF00803; mir-425

Literature search

51 open access papers mention hsa-mir-425
(291 sentences)

Sequence

219172 reads, 790 reads per million, 150 experiments

gaaagcgcuuuggAAUGACACGAUCACUCCCGUUGAgugggcacccgagaagccAUCGGGAAUGUCGUGUCCGCCCagugcucuuuc
(((((.((.((((...(((((((.((.(((((....((((............))))))))).)))))))))...)))).)).)))))

Structure

     c  u    AAU       U  C     UUGA    gcacc 
gaaag gc uugg   GACACGA CA UCCCG    gugg     c
||||| || ||||   ||||||| || |||||    ||||      
cuuuc cg gaCC   CUGUGCU GU AGGGC    UAcc     g
     u  u    CGC       -  A     ----    gaaga 

Annotation confidence High

Comments

The mature sequences were previously named miR-425-5p and miR-425-3p in [2] and here. Landgraf et al. show that the 5' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr3: 49020148-49020234 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-425

Disease association

hsa-mir-425 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-425-5p

• Accession: MIMAT0003393
• Description: Homo sapiens hsa-miR-425-5p mature miRNA
• Sequence: 14 - AAUGACACGAUCACUCCCGUUGA - 36
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-425-3p

• Accession: MIMAT0001343
• Description: Homo sapiens hsa-miR-425-3p mature miRNA
• Sequence: 55 - AUCGGGAAUGUCGUGUCCGCCC - 76
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706