miRBase entry: hsa-mir-425

Stem-loop hsa-mir-425

Homo sapiens hsa-mir-425 precursor miRNA
Gene family
MIPF0000242; mir-425

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR425 is a differentially expressed (DE) microRNA (miRNA) that has been studied in various biological contexts. It has been identified as one of the DE miRNAs in calf and bull testes, along with MIR98, MIR34C, MIR184, MIR18A, MIR136, MIR15A, MIR1388, and MIR210 [PMC9777600]. In breast cancer cells, it has been shown that the long non-coding RNA LINC00899 directly interacts with and binds to MIR425 [PMC6914403]. In the context of breast cancer cases versus controls, the ratio of microRNA concentrations for MIR425 was found to be downregulated in serum samples [PMC9967215]. Additionally, it has been identified as a potential biomarker for breast cancer along with other miRNAs such as MIR21 and MIR155 [PMC9967215]. In tumorigenesis regulation studies, both in vitro and in silico approaches have implicated the involvement of miR425 [PMC5361868]. Furthermore, studies have shown that homozygosity for a deletion involving the gene encoding for miR425 is lethal in mice [PMC8520725]. In other cancer types such as cervical cancer and gastric cancer cells, miR425 has also been implicated as a potential biomarker or regulator [PMC8316837] [PMC7238808]. Additionally, it has been proposed as a potential biomarker for pancreatic ductal adenocarcinoma (PDAC) detection along with other miRNAs such as miR31 and miR93 [PMC9599289]. Furthermore, downregulation of miR425 expression has also been observed in hypertrophic cardiomyopathy and myocardial infarction cases [PMC8773242] [PMC9897690].

Literature search
51 open access papers mention hsa-mir-425
(291 sentences)


219173 reads, 1627 reads per million, 150 experiments

     c  u    AAU       U  C     UUGA    gcacc 
gaaag gc uugg   GACACGA CA UCCCG    gugg     c
||||| || ||||   ||||||| || |||||    ||||      
cuuuc cg gaCC   CUGUGCU GU AGGGC    UAcc     g
     u  u    CGC       -  A     ----    gaaga 

Annotation confidence High
Do you think this miRNA is real?
The mature sequences were previously named miR-425-5p and miR-425-3p in [2] and here. Landgraf et al. show that the 5' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr3: 49020148-49020234 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-425
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-425 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-425-5p

Accession MIMAT0003393
Description Homo sapiens hsa-miR-425-5p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets

Mature hsa-miR-425-3p

Accession MIMAT0001343
Description Homo sapiens hsa-miR-425-3p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  4. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706