miRBase entry: mmu-mir-449a

Stem-loop mmu-mir-449a


Accession
MI0001649
Symbol
MGI: Mir449a
Description
Mus musculus mmu-mir-449a precursor miRNA mir-449
Gene
family?
RF00711; mir-449

Literature search
72 open access papers mention mmu-mir-449a
(825 sentences)

Sequence

37383 reads, 1785 reads per million, 88 experiments
cugugugugauggcuUGGCAGUGUAUUGUUAGCUGGUugaguaugugagcggcacCAGCUAACAUGCGACUGCUCUCcuauugcacacaca
.((((((((((((...((((((((((.((((((((((...((......))...)))))))))))))).))))))...))))))))))))..

Structure
-c            cuU      -    U          uga  au 
  ugugugugaugg   GGCAGU GUAU GUUAGCUGGU   gu  g
  ||||||||||||   |||||| |||| ||||||||||   ||   
  acacacguuauc   UCGUCA CGUA CAAUCGACca   cg  u
ac            CUC      G    -          cgg  ag 


Annotation confidence High
Do you think this miRNA is real?
Comments
Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).

Genome context
chr13: 113037534-113037624 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from mmu-mir-449a
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-449a-5p

Accession MIMAT0001542
Description Mus musculus mmu-miR-449a-5p mature miRNA
Sequence 16 - UGGCAGUGUAUUGUUAGCUGGU - 37
Evidence experimental
cloned [2], Illumina [3-4]
Database links
Predicted targets

Mature mmu-miR-449a-3p

Accession MIMAT0017180
Description Mus musculus mmu-miR-449a-3p mature miRNA
Sequence 56 - CAGCUAACAUGCGACUGCUCUC - 77
Evidence experimental
Illumina [4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  3. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  4. PubMed ID: 15735639
    Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
    "Nature (2005) 434:338-345