Stem-loop hsa-mir-450a-1

Accession

MI0001652

Symbol

HGNC: MIR450A1

Description

Homo sapiens hsa-mir-450a-1 precursor miRNA

Gene family

MIPF0000128; mir-450

Literature search

20 open access papers mention hsa-mir-450a-1
(42 sentences)

Sequence

22174 reads, 777 reads per million, 109 experiments

aaacgauacuaaacuguUUUUGCGAUGUGUUCCUAAUAUgcacuauaaauauAUUGGGAACAUUUUGCAUGUAUaguuuuguaucaauaua
....(((((.(((((((...(((((.((((((((((((((.........)))))))))))))).)))))...))))))).)))))......

Structure

--aaac     u       UUU     U              cac 
      gauac aaacugu   UGCGA GUGUUCCUAAUAUg   u
      ||||| |||||||   ||||| ||||||||||||||   a
      cuaug uuugaUA   ACGUU UACAAGGGUUAuau   u
auauaa     u       UGU     U              aaa 

Annotation confidence High

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR238. The sequence is unrelated to C. elegans mir-238 (MIR:MI0000313).

Genome context

chrX: 134540341-134540431 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-450a-1

Disease association

hsa-mir-450a-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-450a-5p

• Accession: MIMAT0001545
• Description: Homo sapiens hsa-miR-450a-5p mature miRNA
• Sequence: 18 - UUUUGCGAUGUGUUCCUAAUAU - 39
• Evidence: experimental ; array-cloned [1,3], cloned [1,4]

Mature hsa-miR-450a-1-3p

• Accession: MIMAT0022700
• Description: Homo sapiens hsa-miR-450a-1-3p mature miRNA
• Sequence: 53 - AUUGGGAACAUUUUGCAUGUAU - 74
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


4. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345


5. PubMed ID: 23226537
   The repertoire and features of human platelet microRNAs
   Plé H, Landry P, Benham A, Coarfa C, Gunaratne PH, Provost P
   PLoS One (2012) 7:e50746