Stem-loop hsa-mir-409

Accession

MI0001735

Symbol

HGNC: MIR409

Description

Homo sapiens hsa-mir-409 precursor miRNA

Literature search

56 open access papers mention hsa-mir-409
(192 sentences)

Sequence

8528 reads, 22 reads per million, 121 experiments

ugguacucggggagAGGUUACCCGAGCAACUUUGCAUcuggacgacGAAUGUUGCUCGGUGAACCCCUuuucgguauca
((((((.(((((((.((((..((((((((((((((........).)))).)))))))))..)))).)))))))))))))

Structure

      u       A    AC         -    - AUc 
ugguac cggggag GGUU  CCGAGCAAC UUUG C   u
|||||| ||||||| ||||  ||||||||| |||| |    
acuaug gcuuuUC CCAA  GGCUCGUUG AAGc g   g
      -       C    GU         U    a cag 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr14: 101065300-101065378 [+]

Clustered miRNAs

10 other miRNAs are < 10 kb from hsa-mir-409

Disease association

hsa-mir-409 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-409-5p

• Accession: MIMAT0001638
• Description: Homo sapiens hsa-miR-409-5p mature miRNA
• Sequence: 15 - AGGUUACCCGAGCAACUUUGCAU - 37
• Evidence: experimental ; cloned [1,3-4]

Mature hsa-miR-409-3p

• Accession: MIMAT0001639
• Description: Homo sapiens hsa-miR-409-3p mature miRNA
• Sequence: 47 - GAAUGUUGCUCGGUGAACCCCU - 68
• Evidence: experimental ; cloned [1,3-4], array-cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


3. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267