Stem-loop mml-mir-99a

Accession

MI0002702

Description

Macaca mulatta mml-mir-99a precursor miRNA

Sequence

215532 reads, 1741 reads per million, 8 experiments

cccauuggcauaAACCCGUAGAUCCGAUCUUGUGgugaaguggaccgcacAAGCUCGCUUCUAUGGGUCUGugucagugug
..((((((((((.(((((((((..(((.((((((.((........)))))))).)))..))))))))).))))))))))..

Structure

cc          A         UC   U      g  aag 
  cauuggcaua ACCCGUAGA  CGA CUUGUG ug   u
  |||||||||| |||||||||  ||| |||||| ||    
  gugacuguGU UGGGUAUCU  GCU GAAcac gc   g
gu          C         UC   C      -  cag 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context

chr3: 31071139-31071219 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mml-mir-99a

Mature mml-miR-99a-5p

• Accession: MIMAT0002410
• Description: Macaca mulatta mml-miR-99a-5p mature miRNA
• Sequence: 13 - AACCCGUAGAUCCGAUCUUGUG - 34
• Evidence: experimental ; cloned [1], Illumina [3]

Mature mml-miR-99a-3p

• Accession: MIMAT0026579
• Description: Macaca mulatta mml-miR-99a-3p mature miRNA
• Sequence: 51 - AAGCUCGCUUCUAUGGGUCUG - 71
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


2. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45