Stem-loop mml-mir-181c

Accession

MI0002811

Description

Macaca mulatta mml-mir-181c precursor miRNA

Literature search

3 open access papers mention mml-mir-181c
(4 sentences)

Sequence

84165 reads, 553 reads per million, 8 experiments

cggagaauuugccaaggguuugggggAACAUUCAACCUGUCGGUGAGUuugggcagcucaggcaaaCCAUCGACCGUUGAGUGGACCcugagaccuggacuugccauccu
.(((......((((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).)))))))).)......))).

Structure

c   gaauuu -   ag     g    AA        CU       A     ggca 
 gga      g cca  gguuu gggg  CAUUCAAC  GUCGGUG GUuug    g
 |||      | |||  ||||| ||||  ||||||||  ||||||| |||||    c
 ccu      c ggu  ccaga ucCC  GUGAGUUG  CAGCUAC Caaac    u
u   accguu a   --     g    AG        -C       -     ggac 

Annotation confidence Medium

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context

chr19: 13878531-13878640 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mml-mir-181c

Mature mml-miR-181c-5p

• Accession: MIMAT0002509
• Description: Macaca mulatta mml-miR-181c-5p mature miRNA
• Sequence: 27 - AACAUUCAACCUGUCGGUGAGU - 48
• Evidence: experimental ; cloned [1], Illumina [3]

Mature mml-miR-181c-3p

• Accession: MIMAT0026587
• Description: Macaca mulatta mml-miR-181c-3p mature miRNA
• Sequence: 67 - CCAUCGACCGUUGAGUGGACC - 87
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


2. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45