Stem-loop mml-mir-181b-1

Accession

MI0002932

Description

Macaca mulatta mml-mir-181b-1 precursor miRNA

Literature search

3 open access papers mention mml-mir-181b-1
(7 sentences)

Sequence

361232 reads, 2385 reads per million, 8 experiments

ccugugcagagauuauuuuuuaaaaggucacaaucAACAUUCAUUGCUGUCGGUGGGUUgaacuguguagacaagcucACUGAACAAUGAAUGCAACuguggccccgcuu
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......

Structure

ccugugcagagauuauuuuuuaaaa       aucAA         CUG          gaac   g 
                         ggucaca     CAUUCAUUG   UCGGUGGGUU    ugu u
                         |||||||     |||||||||   ||||||||||    |||  
                         ccggugu     GUAAGUAAC   AGUCAcucga    aca a
-------------------uucgcc       -CAAC         --A          ----   g 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context

chr1: 167910438-167910547 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mml-mir-181b-1

Mature mml-miR-181b-5p

• Accession: MIMAT0002623
• Description: Macaca mulatta mml-miR-181b-5p mature miRNA
• Sequence: 36 - AACAUUCAUUGCUGUCGGUGGGUU - 59
• Evidence: experimental ; Illumina [2]

Mature mml-miR-181b-1-3p

• Accession: MIMAT0026592
• Description: Macaca mulatta mml-miR-181b-1-3p mature miRNA
• Sequence: 79 - ACUGAACAAUGAAUGCAAC - 97
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


2. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45