Stem-loop mml-mir-16-1

Accession

MI0002958

Description

Macaca mulatta mml-mir-16-1 precursor miRNA

Literature search

3 open access papers mention mml-mir-16-1
(4 sentences)

Sequence

67757 reads, 605 reads per million, 8 experiments

gucagcagugccuUAGCAGCACGUAAAUAUUGGCGuuaagauucuaaaauuaucuCCAGUAUUAACUGUGCUGCUGAAguaagguugac
((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..))))))

Structure

      ag   c          -  A        C u   gauu 
gucagc  ugc uUAGCAGCAC GU AAUAUUGG G uaa    c
||||||  ||| |||||||||| || |||||||| | |||     
caguug  aug AGUCGUCGUG CA UUAUGACC c auu    u
      ga   A          U  A        u u   aaaa 

Annotation confidence Medium

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context

chr17: 29400064-29400152 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mml-mir-16-1

Mature mml-miR-16-5p

• Accession: MIMAT0002651
• Description: Macaca mulatta mml-miR-16-5p mature miRNA
• Sequence: 14 - UAGCAGCACGUAAAUAUUGGCG - 35
• Evidence: experimental ; Illumina [2]

Mature mml-miR-16-1-3p

• Accession: MIMAT0026594
• Description: Macaca mulatta mml-miR-16-1-3p mature miRNA
• Sequence: 56 - CCAGUAUUAACUGUGCUGCUGAA - 78
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


2. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45