Stem-loop mml-mir-17

Accession

MI0003001

Description

Macaca mulatta mml-mir-17 precursor miRNA

Literature search

4 open access papers mention mml-mir-17
(6 sentences)

Sequence

26491 reads, 313 reads per million, 8 experiments

gucagaauaauguCAAAGUGCUUACAGUGCAGGUAGUgauaugugcaucuACUGCAGUGAAGGCACUUGUagcauuauggugac
((((..(((((((..((((((((.((.(((((.(((((.......)).)))))))).)).))))))))...)))))))..))))

Structure

    ga       -CA        A  G     G   -  au 
guca  auaaugu   AAGUGCUU CA UGCAG UAG Ug  a
||||  |||||||   |||||||| || ||||| ||| ||  u
cagu  uauuacg   UUCACGGA GU ACGUC Auc ac  g
    gg       aUG        A  G     -   u  gu 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [2]. The expression of this mature miRNA was validated by Miska et al [1].

Genome context

chr17: 73096107-73096190 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from mml-mir-17

Mature mml-miR-17-5p

• Accession: MIMAT0002700
• Description: Macaca mulatta mml-miR-17-5p mature miRNA
• Sequence: 14 - CAAAGUGCUUACAGUGCAGGUAGU - 37
• Evidence: experimental ; cloned [1]

Mature mml-miR-17-3p

• Accession: MIMAT0002701
• Description: Macaca mulatta mml-miR-17-3p mature miRNA
• Sequence: 51 - ACUGCAGUGAAGGCACUUGU - 70
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


2. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24