Stem-loop mml-mir-27a

Accession

MI0003052

Description

Macaca mulatta mml-mir-27a precursor miRNA mir-27

Gene
family

RF00644; mir-27

Literature search

1 open access papers mention mml-mir-27a
(2 sentences)

Sequence

99262 reads, 669 reads per million, 9 experiments

cugaggagcAGGGCUUAGCUGCUUGUGAGCAggguccacaccaagucgugUUCACAGUGGCUAAGUUCCGCCccccag
(((.((.((.(((((((((((((.(((((((.((.(........))).)))))))))))))))))))).)).)).)))

Structure

   a  a  A             U       g  u cac 
cug gg gc GGGCUUAGCUGCU GUGAGCA gg c   a
||| || || ||||||||||||| ||||||| || |    
gac cc CG CUUGAAUCGGUGA CACUUgu cu g   c
   c  C  C             -       g  - aac 

Annotation confidence High

Comments

Berezikov et al. used primers designed from human miRNA gene flanking sequence to amplify miRNA precursor regions in primates [1]. The expression of the mature miRNA was not validated.

Genome context

chr19: 13839013-13839090 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from mml-mir-27a

Mature mml-miR-27a-3p

• Accession: MIMAT0002753
• Description: Macaca mulatta mml-miR-27a-3p mature miRNA
• Sequence: 51 - UUCACAGUGGCUAAGUUCCGCC - 72
• Evidence: experimental ; Illumina [2]

Mature mml-miR-27a-5p

• Accession: MIMAT0026600
• Description: Macaca mulatta mml-miR-27a-5p mature miRNA
• Sequence: 10 - AGGGCUUAGCUGCUUGUGAGCA - 31
• Evidence: experimental ; Illumina [2]

References

1. PubMed ID: 15652478
   Phylogenetic shadowing and computational identification of human microRNA genes
   "Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E"
   "Cell (2005) 120:21-24


2. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45